6-Chloro-n4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine - CAS 867017-68-3
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
6-Chloro-n4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
Catalog Number:
867017-68-3
Synonyms:
6-Chloro-N4-{3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl}pyrimidine-2,4-diamine;Rho Kinase Inhibitor;ROCK inhibitor;ROCK
CAS Number:
867017-68-3
Description:
6-Chloro-n4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine is potent and highly selective ROCK inhibitor. Its IC50 values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively. It exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. It reduces blood pressure in normotensive and hypertensive rats. It is useful for Anti-cancer.
Molecular Weight:
402.79
Molecular Formula:
C18H13ClF2N6O
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC1=CNC2=NC=CC(=C12)OC3=C(C=C(C=C3F)NC4=CC(=NC(=N4)N)Cl)F
InChI:
InChI=1S/C18H13ClF2N6O/c1-8-7-24-17-15(8)12(2-3-23-17)28-16-10(20)4-9(5-11(16)21)25-14-6-13(19)26-18(22)27-14/h2-7H,1H3,(H,23,24)(H3,22,25,26,27)
InChIKey:
NRSGWEVTVGZDFC-UHFFFAOYSA-N
Targets:
ROCK
Chemical Structure
CAS 867017-68-3 6-Chloro-n4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine

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