6-Azauracil - CAS 461-89-2
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
6-Azauracil
Catalog Number:
461-89-2
Synonyms:
6-Azauracil;461-89-2;1,2,4-Triazine-3,5(2H,4H)-dione;Azauracil;1,2,4-Triazine-3,5-diol;4(6)-Azauracil
CAS Number:
461-89-2
Description:
6-Azauracil inhibits enzymes in nucleoside synthesis and depletes the intracellular GTP/UTP pool. It is being used to identify mutations in transcriptional elongation machinery, as well as mutations in a variety of other pathways.
Molecular Weight:
113.07
Molecular Formula:
C3H3N3O2
Quantity:
Milligrams-Grams
Quality Standard:
Enterprise standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
C1=NNC(=O)NC1=O
InChI:
1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)
InChIKey:
SSPYSWLZOPCOLO-UHFFFAOYSA-N
Targets:
Others
Chemical Structure
CAS 461-89-2 6-Azauracil

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Reference Reading


1.Potential antineoplastics I: substituted 3,5-dioxo-and 3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines.
Ibrahim el-SA, Shams el-Dine SA, Soliman FS, Labouta IM. J Pharm Sci. 1979 Feb;68(2):243-5.
The synthesis of some 6-substituted 3,5-dioxo- and 3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines for possible antineoplastic activity is reported. The assigned structures were substantiated by IR, NMR, and mass spectral studies of representative members of the series. Four compounds were tested against P-388 lymphocytic leukemia and were inactive.