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6,8-dimethylquinoline-3-carboxylicacid; 6,8-Dimethylquinoline-3-carboxylicacid; 213013-16-2; CTK8E5331; MolPort-006-171-002; ZINC32099545
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Reference Reading

1.Enhanced coagulation-photocatalytic treatment of Acid red 73 dye and real textile wastewater using UVA/synthesized MgO nanoparticles.
Jorfi S1, Barzegar G2, Ahmadi M3, Darvishi Cheshmeh Soltani R4, Alah Jafarzadeh Haghighifard N5, Takdastan A6, Saeedi R7, Abtahi M8. J Environ Manage. 2016 Apr 14;177:111-118. doi: 10.1016/j.jenvman.2016.04.005. [Epub ahead of print]
Sequencing coagulation - photocatalytic degradation using UVA/MgO nanoparticles process was investigated for Acid red 73dye removal and then treatment of a real textile wastewater. Effective operational parameters including pH and coagulant and photocatalyst dosage were studied in synthetic wastewater and then the process was applied for real wastewater. Both coagulation and photocatalytic processes were pH dependent. At coagulant dosage of 200 mg/L and initial pH of 6, the dye concentration decreased from 200 to 31 mg/L. Complete removal of AR73 was observed with MgO nanoparticles of 0.8 g/L, initial pH of 5 and reaction time of 60 min. Langmuir-Hinshelwood model was well fitted with removal results (R2: 0.939-0.988 for different initial dye concentration). In the case of real textile wastewater, the sequence coagulation-UVA/MgO nanoparticles photocatalytic degradation yielded considerable total COD and TOC removal 98.3% and 86.9%respectively, after 300 min.
2.Mesenchymal stem cell proliferation and mineralization but not osteogenic differentiation are strongly affected by extracellular pH.
Fliefel R1, Popov C2, Tröltzsch M3, Kühnisch J4, Ehrenfeld M3, Otto S3. J Craniomaxillofac Surg. 2016 Mar 19. pii: S1010-5182(16)00081-0. doi: 10.1016/j.jcms.2016.03.003. [Epub ahead of print]
Osteomyelitis is a serious complication in oral and maxillofacial surgery affecting bone healing. Bone remodeling is not only controlled by cellular components but also by ionic and molecular composition of the extracellular fluids in which calcium phosphate salts are precipitated in a pH dependent manner.
3.Advantages of Pure Platelet-Rich Plasma Compared with Leukocyte- and Platelet-Rich Plasma in Treating Rabbit Knee Osteoarthritis.
Yin WJ1, Xu HT1, Sheng JG1, An ZQ1, Guo SC1, Xie XT1, Zhang CQ1. Med Sci Monit. 2016 Apr 17;22:1280-90.
BACKGROUND Concentrated leukocytes in leukocyte- and platelet-rich plasma (L-PRP) may deliver increased levels of pro-inflammatory cytokines to activate the NF-κB signaling pathway, to counter the beneficial effects of growth factors on osteoarthritic cartilage. However, to date no relevant studies have substantiated that in vivo. MATERIAL AND METHODS Autologous L-PRP and pure platelet-rich plasma (P-PRP) were prepared, measured for componential composition, and injected intra-articularly after 4, 5, and 6 weeks post-anterior cruciate ligament transection. Caffeic acid phenethyl ester (CAPE) was injected intraperitoneally to inhibit NF-κB activation. All rabbits were sacrificed after 8 weeks postoperative. Enzyme-linked immunosorbent assays were performed to determine interleukin 1β (IL-1β) and prostaglandin E2 (PGE2) concentrations in the synovial fluid, Indian ink staining was performed for gross morphological assessment, and hematoxylin and eosin staining and toluidine blue staining were performed for histological assessment.
4.Cognitive Profile of Zonisamide and Valproic Acid in the Treatment of Idiopathic Generalized Epilepsy: A Comparative Observational Study.
Ramirez-García T1, Serrano-Castro PJ2,3, Alonso-Morillejo E4, Perea-Justicia P1, Iglesias-Espinosa M1, Parrón-Carreño T5. Neurol Ther. 2016 Apr 16. [Epub ahead of print]
INTRODUCTION: Calls for an alternative to valproic acid (VPA) as drug of choice for idiopathic generalized epilepsies (IGEs) have intensified since the recent International League Against Epilepsy recommendation that the drug should not be administered to women of childbearing age. Zonisamide (ZNS), a third-generation antiepileptic drug, has proven effective in generalized seizures and could be considered an alternative to VPA in this population.