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5-(Trifluoromethyl)-1H-indole-3-carboxylic acid - CAS 948579-72-4

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Category
Main Product
Product Name
5-(Trifluoromethyl)-1H-indole-3-carboxylic acid
Catalog Number
948579-72-4
CAS Number
948579-72-4
Molecular Weight
229.16
Molecular Formula
C10H6F3NO2
COA
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MSDS
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Structure
CAS 948579-72-4 5-(Trifluoromethyl)-1H-indole-3-carboxylic acid
Specification
Purity
95%
Density
1.549
Reference Reading
1.Serotonin relaxes porcine pial veins.
Lee TJ1, Ueno M, Sunagane N, Sun MH. Am J Physiol. 1994 Mar;266(3 Pt 2):H1000-6.
The effect of serotonin [5-hydroxytryptamine (5-HT)] on pial venous tone of the pig was examined using in vitro tissue bath techniques. Isolated pial venous rings exhibited spontaneous rhythmic contractions (SRC) on mechanical stretching and/or applications of several vasoactive substances, including norepinephrine. On the other hand, KCl induced sustained active muscle tone (SAT) without SRC. The SRC induced by mechanical stretching were not affected by tetrodotoxin, nitro-L-arginine, alpha- and beta-adrenergic, histaminergic, and muscarinic receptor antagonists, indicating that the SRC in porcine pial veins are of myogenic origin. The SRC induced by stretching or applications of vasoactive substances and SAT induced by KCl were inhibited by 5-HT in a concentration-dependent manner. The inhibition was prevented by methysergide and methiothepin but not by ketanserin, propranolol, 3 alpha-tropanyl-1H-indole-3-carboxylic acid ester, hemoglobin, or nitro-L-arginine.
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