5-Methoxy-quinazoline-2,4-diamine - CAS 27018-21-9

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Category
Main Product
Product Name
5-Methoxy-quinazoline-2,4-diamine
Catalog Number
27018-21-9
Synonyms
5-Methoxy-quinazoline-2,4-diamine; 5-Methoxy-2,4-diaminoquinazoline; 2,4-Quinazolinediamine, 5-methoxy-; 5-Methoxy-2,4-quinazolinediamine; Brn 0746085
CAS Number
27018-21-9
Molecular Weight
190.2019
Molecular Formula
C9H10N4O
COA
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MSDS
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Canonical SMILES
COC1=CC=CC2=C1C(=NC(=N2)N)N
InChI
InChI=1S/C9H10N4O/c1-14-6-4-2-3-5-7(6)8(10)13-9(11)12-5/h2-4H,1H3,(H4,10,11,12,13)
InChIKey
FYEWYRWGCVGNJW-UHFFFAOYSA-N
Structure
CAS 27018-21-9 5-Methoxy-quinazoline-2,4-diamine
Specification
Purity
95%
Boiling Point
484.8ºC at 760mmHg
Density
1.372g/cm3
Reference Reading
1.Design, synthesis and antiproliferative activity of novel 5-nitropyrimidine-2,4-diamine derivatives bearing alkyl acetate moiety.
Zhao PL1, Li YH2, Yang HK2, Chen P2, Zhang B2, Sun Q2, Li Q2, You WW3. Eur J Med Chem. 2016 Apr 16;118:161-169. doi: 10.1016/j.ejmech.2016.04.038. [Epub ahead of print]
In order to discover new anticancer drug leads, a series of novel alkylamino pyrimidine derivatives were designed and synthesized based on our previous work via a ring-opening strategy. Biological evaluation with four human cancer cell lines (MDA-MB-231, A549, HepG2, and MCF-7) showed that most of these compounds possessed moderate to potent antiproliferative activities. The most promising compound 7w displayed a three-fold improvement compared with commercial anticancer drug fluorouracil in inhibiting HepG2 cell proliferation with IC50 value of 10.37 μM. Moreover, flow-activated cell sorting analysis suggested that compound 7w mainly arrested HepG2 cells in G2/M stage. Hence, it could serve as a promising lead for the design of novel anticancer small-molecule drugs.
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