5-hydroxypyrazine-2-carboxylic acid - CAS 34604-60-9
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
5-hydroxypyrazine-2-carboxylic acid
Catalog Number:
34604-60-9
Synonyms:
4,5-Dihydro-5-oxopyrazinecarboxylic Acid; 5-Hydroxypyrazinecarboxylic Acid; 5-Hydroxypyrazinoic acid; 5-Oxo-4,5-dihydropyrazine-2-carboxylic Acid
CAS Number:
34604-60-9
Description:
A versatile building block for the synthesis of new antituberculous agents. A metabolite of Pyrazinamide.
Molecular Weight:
140.1
Molecular Formula:
C5H4N2O3
COA:
Inquire
MSDS:
Inquire
Targets:
Antibacterial
Chemical Structure
CAS 34604-60-9 5-hydroxypyrazine-2-carboxylic acid

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Reference Reading


1.Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Pyrazinamide
C. BECKER, J.B. DRESSMAN. JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 97, NO. 9, SEPTEMBER 2008
The purpose and scope of this series of monographs have been previously discussed. Summarized in few words, the aim is to evaluate all pertinent data available from literature sources for a given API to assess the risks associated with a biowaiver. For these purposes, risk is defined as the probability of an incorrect biowaiver decision as well as the consequences of the decision in terms of public health and individual patient risks. On the basis of these considerations, a recommendation can be made as to whether a biowaiver approval is advisable or not. This systematic approach to recommend or advise against a biowaiver decisions is referred to in the recently published World Health Organization (WHO) Guideline. It is pointed out that these monographs do not simply apply this WHO Guideline, nor the FDA and/or EMEA Guidance, but also want to serve as a critical validation of these regulatory documents. Biowaiver monographs have already been published for acetaminophen (INN: paracetamol), amitriptyline, atenolol, chloroquine, cimetidine, ethambutol, ibuprofen, isoniazid, prednisolone, prednisone, propranolol, ranitidine, and verapamil. They are also available online at the website of the International Pharmaceutical Federation FIP.