5-Aminolevulinic acid methyl ester hydroChloride - CAS 79416-27-6
Not Intended for Therapeutic Use. For research use only.
Product Name:
5-Aminolevulinic acid methyl ester hydroChloride
Catalog Number:
5-Amino-4-oxopentanoic Acid Methyl Ester Hydrochloride (1:1); Methyl 5-Amino-4-oxopentanoate Hydrochloride; Methyl 5-Aminolevulinate Hydrochloride; Methyl ALA Ester Hydrochloride; Methyl Aminolevulinate Hydrochloride; Metvix; P 1202; δ-Aminolevulinic Acid Methyl Ester Hydrochloride;
CAS Number:
5-Aminolevulinic Acid Methyl Ester Hydrochlorideis the methyl ester of Aminolevulinic Acid. It shows much higher lipophilicity and highly efficient at inducing protoporphyrin IXproduction in cell culture.
Molecular Weight:
Molecular Formula:
Quality Standard:
In-house standard
Canonical SMILES:
Chemical Structure
CAS 79416-27-6 5-Aminolevulinic acid methyl ester hydroChloride

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Reference Reading

1.A Strategy Using Photodynamic Therapy and Clofibric Acid to Treat Peritoneal Dissemination of Ovarian Cancer.
Yokoyama Y1, Shigeto T, Miura R, Kobayashi A, Mizunuma M, Yamauchi A, Futagami M, Mizunuma H. Asian Pac J Cancer Prev. 2016;17(2):775-9.
BACKGROUND: The current study examined the effectiveness of concurrent therapy using photodynamic therapy (PDT) and clofibric acid (CA) to treat peritoneal carcinomatosis resulting from ovarian cancer.
2.Transdermal delivery from a lipid sponge phase--iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester.
Merclin N1, Bender J, Sparr E, Guy RH, Ehrsson H, Engström S. J Control Release. 2004 Nov 24;100(2):191-8.
The hydrochloride salts of 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA), respectively, were dissolved in a lipid sponge phase comprising monoolein, propylene glycol and aqueous buffer at concentrations of approximately 0.25% and 16% w/w m-ALA. The iontophoretic and passive delivery of ALA and m-ALA from this formulation through porcine skin in vitro were measured and compared to formulations used in clinical practice, 20% w/w ALA in Unguentum M and Metvix (a cream containing 16% w/w m-ALA). A sponge phase with 16% w/w m-ALA showed a higher passive flux (approximately 140 nmol cm(-2) h(-1) at 5 h) but a lower iontophoretic flux (approximately 800 nmol cm(-2) h(-1) at 5 h) compared to the clinically used products but the differences are hardly significant due to large standard deviations. ALA and m-ALA in sponge phase formulation showed iontophoretic fluxes in the range 80-100 nmol cm(-2) h(-1) at 3 h, i.e. values comparable to the passive fluxes from the more concentrated vehicles.
3.Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy.
Gerritsen MJ1, Smits T, Kleinpenning MM, van de Kerkhof PC, van Erp PE. Dermatology. 2009;218(3):193-202. doi: 10.1159/000183753. Epub 2008 Dec 11.
The response rates of photodynamic therapy (PDT) vary widely. Limited uptake of topically applied 5-aminolaevulinic acid (ALA), or its methyl ester (MAL), and suboptimal production of protoporphyrin IX (PpIX) may account for these differences. Recently, we demonstrated that hyperkeratosis is an important negative factor in ALA uptake. This review has its focus on pretreatment of the skin in order to improve the clinical outcome of ALA/MAL PDT. Pretreatment of hyperkeratosis can be achieved with keratolytics, curettage/debulking, tape stripping, microdermabrasion or laser ablation. Penetration enhancers may alter the composition or organization of the intercellular lipids of the stratum corneum. Several studies have been performed on the use of dimethyl sulfoxide, azone, glycolic acid, oleic acid and iontophoresis to increase the penetration of ALA. As PpIX production is also dominated by temperature-dependent processes, elevating skin temperature during ALA application may also improve treatment results.