5-Aminolevulinic acid methyl ester hydroChloride - CAS 79416-27-6
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
5-Aminolevulinic acid methyl ester hydroChloride
Catalog Number:
79416-27-6
Synonyms:
5-Amino-4-oxopentanoic Acid Methyl Ester Hydrochloride (1:1); Methyl 5-Amino-4-oxopentanoate Hydrochloride; Methyl 5-Aminolevulinate Hydrochloride; Methyl ALA Ester Hydrochloride; Methyl Aminolevulinate Hydrochloride; Metvix; P 1202; δ-Aminolevulinic Acid Methyl Ester Hydrochloride;
CAS Number:
79416-27-6
Description:
5-Aminolevulinic Acid Methyl Ester Hydrochlorideis the methyl ester of Aminolevulinic Acid. It shows much higher lipophilicity and highly efficient at inducing protoporphyrin IXproduction in cell culture.
Molecular Weight:
181.62
Molecular Formula:
C6H11NO3.HCl
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
COC(=O)CCC(=O)CN.Cl
InChI:
InChI=1S/C6H11NO3.ClH/c1-10-6(9)3-2-5(8)4-7;/h2-4,7H2,1H3;1H
InChIKey:
UJYSYPVQHFNBML-UHFFFAOYSA-N
Targets:
Others
Chemical Structure
CAS 79416-27-6 5-Aminolevulinic acid methyl ester hydroChloride

Related Products


CAS 2185-98-0 Ocaphane Hydrochloride

Ocaphane Hydrochloride
(CAS: 2185-98-0)

Ocaphane Hydrochloride is a strong antitumor agent used on a number of animal tumors such as Brown-Pearce carcinoma but is fairly toxic to hemopoietic organs.

CAS 80681-45-4 Prim-o-glucosylcimifugin

Prim-o-glucosylcimifugin
(CAS: 80681-45-4)

Prim-O-glucosylcimifugin is a natural product extracted from the root of Saposhnikovia divaricata (Turcz.) Schischk. It can inhibit the proliferation of SMC(smo...

CAS 478-08-0 Lucidin

Lucidin
(CAS: 478-08-0)

Lucidin is a natural component of Rubia tinctorum L.

RO 5263397
(CAS: 1357266-05-7)

RO5263397 is a selective trace amine-associated receptor 1(TAAR1) agonist. TAAR1 is a drug discovery target for cocaine addiction. RO5263397 is efficacious in r...

CAS 223445-75-8 Atagabalin

Atagabalin
(CAS: 223445-75-8)

Atagabalin, also referred to PD-0200,390, is a gabamimetic agent developed as a treatment for insomnia but was discontinued following unsatisfactory trial resul...

CAS 55290-63-6 Atractylodin

Atractylodin
(CAS: 55290-63-6)

Atractylodin is an active component of the essential oil contained in the rhizomes of Atractylodes lancea and A.

CAS 616204-22-9 Argireline

Argireline
(CAS: 616204-22-9)

Argireline is a syntheticpeptide as a fragment of SNAP-25, a substrate of Botulinum toxin (Botox). for anti-wrinkle cosmetics ingredient.

CP-71362
(CAS: 112227-15-3)

CP-71362 is a pentapeptide renin inhibitor. It is selective for the canine enzyme.

CAS 23288-49-5 Probucol

Probucol
(CAS: 23288-49-5)

Enhances selective uptake of HDL-associated cholesteryl esters.

CAS 103597-45-1 Diurethane dimethacrylate

Diurethane dimethacrylate
(CAS: 103597-45-1)

Bisoctrizole, a benzotriazole derivative, is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA ray. It could also reflect and scatte...

CAS 20283-92-5 Rosmarinic acid

Rosmarinic acid
(CAS: 20283-92-5)

Rosmarinic acid is a naturally occurring hydroxylated compound occured in many plants. Rosmarinic acid exhibits agonist activity at GPR35 and shows antiviral, a...

CAS 36338-96-2 Safflower Yellow

Safflower Yellow
(CAS: 36338-96-2)

Extract from Carthamin, widely used for the treatment of acute ischemic stroke by acting directly on BV2 microglia.

Endochin
(CAS: 354155-51-4)

Endochin is an experimental antimalarial which was known to be causal prophylactic and potent erythrocytic stage agents in avian models.

CAS 73590-85-9 OMeprazole sulphide

OMeprazole sulphide
(CAS: 73590-85-9)

Omeprazole sulphide is a metabolite of Omeprazole. It is an intermediate used in the production of the gastric proton pump inhibitors, omeprazole and esomeprazo...

CAS 126643-37-6 KT 5823

KT 5823
(CAS: 126643-37-6)

KT 5823 is a cell-permeable, selective inhibitor of cGMP-dependent protein kinase (PKG) (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA re...

CAS 112665-43-7 Seratrodast

Seratrodast
(CAS: 112665-43-7)

Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist used primarily in the treatment of asthma.

CAS 282526-98-1 Cetilistat

Cetilistat
(CAS: 282526-98-1)

Cetilistat, also known as ATL-962, is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic li...

GSK-1268997
(CAS: 1414375-50-0)

GSK-1268997 is one of a metabolite of Pazopanib which is a selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits an...

CB 3703
(CAS: 32093-09-7)

CB 3703 is an inhibitor of hydrofolate reductase.

ML192
(CAS: 460331-61-7)

ML192 is a selective ligands for GPR55 with 1080 nM potency for GPR55 and >45-fold antagonist and agonist selectivity against GPR35, CB1 and CB2.

Reference Reading


1.A Strategy Using Photodynamic Therapy and Clofibric Acid to Treat Peritoneal Dissemination of Ovarian Cancer.
Yokoyama Y1, Shigeto T, Miura R, Kobayashi A, Mizunuma M, Yamauchi A, Futagami M, Mizunuma H. Asian Pac J Cancer Prev. 2016;17(2):775-9.
BACKGROUND: The current study examined the effectiveness of concurrent therapy using photodynamic therapy (PDT) and clofibric acid (CA) to treat peritoneal carcinomatosis resulting from ovarian cancer.
2.Transdermal delivery from a lipid sponge phase--iontophoretic and passive transport in vitro of 5-aminolevulinic acid and its methyl ester.
Merclin N1, Bender J, Sparr E, Guy RH, Ehrsson H, Engström S. J Control Release. 2004 Nov 24;100(2):191-8.
The hydrochloride salts of 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA), respectively, were dissolved in a lipid sponge phase comprising monoolein, propylene glycol and aqueous buffer at concentrations of approximately 0.25% and 16% w/w m-ALA. The iontophoretic and passive delivery of ALA and m-ALA from this formulation through porcine skin in vitro were measured and compared to formulations used in clinical practice, 20% w/w ALA in Unguentum M and Metvix (a cream containing 16% w/w m-ALA). A sponge phase with 16% w/w m-ALA showed a higher passive flux (approximately 140 nmol cm(-2) h(-1) at 5 h) but a lower iontophoretic flux (approximately 800 nmol cm(-2) h(-1) at 5 h) compared to the clinically used products but the differences are hardly significant due to large standard deviations. ALA and m-ALA in sponge phase formulation showed iontophoretic fluxes in the range 80-100 nmol cm(-2) h(-1) at 3 h, i.e. values comparable to the passive fluxes from the more concentrated vehicles.
3.Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy.
Gerritsen MJ1, Smits T, Kleinpenning MM, van de Kerkhof PC, van Erp PE. Dermatology. 2009;218(3):193-202. doi: 10.1159/000183753. Epub 2008 Dec 11.
The response rates of photodynamic therapy (PDT) vary widely. Limited uptake of topically applied 5-aminolaevulinic acid (ALA), or its methyl ester (MAL), and suboptimal production of protoporphyrin IX (PpIX) may account for these differences. Recently, we demonstrated that hyperkeratosis is an important negative factor in ALA uptake. This review has its focus on pretreatment of the skin in order to improve the clinical outcome of ALA/MAL PDT. Pretreatment of hyperkeratosis can be achieved with keratolytics, curettage/debulking, tape stripping, microdermabrasion or laser ablation. Penetration enhancers may alter the composition or organization of the intercellular lipids of the stratum corneum. Several studies have been performed on the use of dimethyl sulfoxide, azone, glycolic acid, oleic acid and iontophoresis to increase the penetration of ALA. As PpIX production is also dominated by temperature-dependent processes, elevating skin temperature during ALA application may also improve treatment results.