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5-(5-CHLORO-2-HYDROXY-4-METHYLPHENYL)-1& - CAS 213690-56-3

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Category
Main Product
Product Name
5-(5-CHLORO-2-HYDROXY-4-METHYLPHENYL)-1&
Catalog Number
213690-56-3
Synonyms
5-(5-CHLORO-2-HYDROXY-4-METHYLPHENYL)-1&
CAS Number
213690-56-3
Molecular Weight
284.745
Molecular Formula
C16H13ClN2O
COA
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MSDS
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Canonical SMILES
CC1=CC(=O)C(=C2C=CNN2C3=CC=CC=C3)C=C1Cl
InChI
InChI=1S/C16H13ClN2O/c1-11-9-16(20)13(10-14(11)17)15-7-8-18-19(15)12-5-3-2-4-6-12/h2-10,18H,1H3
InChIKey
FAJRZMAQVOUTCW-UHFFFAOYSA-N
Structure
CAS 213690-56-3 5-(5-CHLORO-2-HYDROXY-4-METHYLPHENYL)-1&
Specification
Purity
95%
Melting Point
202-206ºC(lit.)
Reference Reading
1.Development and validation of an HPLC method for the determination of dibenzoylmethane in rat plasma and its application to the pharmacokinetic study.
Shen G1, Hong JL, Kong AN. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):56-61. Epub 2007 Jan 10.
A highly sensitive and simple high-performance liquid chromatographic (HPLC) assay has been developed and validated for the quantification of dibenzoylmethane (DBM) in rat plasma. DBM and internal standard (I.S.) 1-(5-chloro-2-hydroxy-4-methylphenyl)-3-phenyl-1,3-propanedione (CHMPP) were extracted from rat plasma by ethyl acetate/methanol (95:5, v/v) and analyzed using reverse-phase gradient elution with a Phenomenex Gemini C18 5-mum column. A gradient of mobile phase (mobile phase A: water/methanol (80:20, v/v) with 0.1% TFA and mobile phase B: acetonitrile with 0.1% TFA) at a flow rate of 0.2 mL/min, and ultraviolet (UV) detection at 335 nm were utilized. The lower limit of quantification (LLOQ) using 50 microL rat plasma was 0.05 microg/mL. The calibration curve was linear over a concentration range of 0.05-20 microg/mL. The mean recoveries were 80.6+/-5.7, 83.4+/-1.6 and 77.1+/-3.4% with quality control (QC) level of 0.05, 1 and 20 microg/mL, respectively.
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