(4S,2RS)-2,5,5-TRIMETHYLTHIAZOLIDINE-4-CARBOXYLIC ACID - CAS 212755-85-6
Catalog number: 212755-85-6
Category: Main Product
Molecular Formula:
C7H13NO2S
Molecular Weight:
175.25
COA:
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Purity:
95%
Synonyms:
CHEBI:141059; (4S)-2,5,5-trimethyl-1,3-thiazolidine-4-carboxylicacid; (S)-2,5,5-Trimethyl-thiazolidine-4-carboxylicacid; SBB017062; 212755-85-6; AC1MBG3I
MSDS:
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Boiling Point:
316.8ºC at 760mmHg
Melting Point:
166-168ºC
Density:
1.131g/cm3
InChIKey:
MQQSPQRNCBFBSG-AKGZTFGVSA-N
InChI:
InChI=1S/C7H13NO2S/c1-4-8-5(6(9)10)7(2,3)11-4/h4-5,8H,1-3H3,(H,9,10)/t4?,5-/m0/s1
Canonical SMILES:
CC1NC(C(S1)(C)C)C(=O)O
1.Liquid chromatography/tandem mass spectrometry determination of (4S,2RS)-2,5,5-trimethylthiazolidine-4-carboxylic acid, a stable adduct formed between D-(-)-penicillamine and acetaldehyde (main biological metabolite of ethanol), in plasma, liver and brain rat tissues.
Serrano E1, Pozo OJ, Beltrán J, Hernández F, Font L, Miquel M, Aragon CM. Rapid Commun Mass Spectrom. 2007;21(7):1221-9.
Acetaldehyde, the main biological metabolite of ethanol, is nowadays considered to mediate some ethanol-induced effects. Previous studies on alcohol effect attenuation have shown that D-(-)-penicillamine (3-mercapto-D-valine), a thiol amino acid, acts as an effective agent for the inactivation of acetaldehyde. In the study reported here, laboratory rats were treated with ethanol and D-(-)-penicillamine at different doses looking for the interaction (in vivo) of D-(-)-penicillamine with metabolically formed acetaldehyde following a condensation reaction to form the stable adduct (4S,2RS)-2,5,5-trimethylthiazolidine-4-carboxylic acid (TMTCA). A novel and rapid procedure based on liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS) was developed for quantification and reliable identification of TMTCA in different rat tissues, including plasma, liver and brain. Firstly, plasma was obtained from whole blood. Then, proteins were precipitated from plasma, brain and liver extracts with acetonitrile and the clarified extracts diluted 10-fold.
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CAS 212755-85-6 (4S,2RS)-2,5,5-TRIMETHYLTHIAZOLIDINE-4-CARBOXYLIC ACID

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