4-Trifluoromethylphenylboronic acid - CAS 128796-39-4
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
4-Trifluoromethylphenylboronic acid
Catalog Number:
128796-39-4
Synonyms:
P-(TRIFLUOROMETHYL)PHENYLBORONIC ACID;RARECHEM AH PB 0095;4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID;4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID;ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLUENEBORONIC ACID;ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLYLBORONIC ACID
CAS Number:
128796-39-4
Description:
4-(Trifluoromethyl)phenylboronic acid is a very useful building block for chemical synthesis
Molecular Weight:
189.93
Molecular Formula:
C7H6BF3O2
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
B(C1=CC=C(C=C1)C(F)(F)F)(O)O
InChI:
InChI=1S/C7H6BF3O2/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4,12-13H
InChIKey:
ALMFIOZYDASRRC-UHFFFAOYSA-N
Targets:
Others
Chemical Structure
CAS 128796-39-4 4-Trifluoromethylphenylboronic acid

Related Products


FW1256
(CAS: 117089-08-4)

Exogenous H2S, as we know, has anti-inflammatory effects both in macrophages and in animal models. FW1256 is a slow release H2S dononr and it is much more poten...

CAS 50-01-1 Guanidine Hydrochloride

Guanidine Hydrochloride
(CAS: 50-01-1)

Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denatur...

CAS 13647-35-3 Trilostane

Trilostane
(CAS: 13647-35-3)

Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.

CAS 22033-87-0 TRO 19622

TRO 19622
(CAS: 22033-87-0)

Olesoxime (TRO19622) is an experimental neuroprotective drug. It is the lead compound of Trophos' cholesterol-oxime compound family of mitochondrial pore modula...

CAS 543-15-7 Heptaminol Hydrochloride

Heptaminol Hydrochloride
(CAS: 543-15-7)

Heptaminol Hydrochloride is an amino alcohol which is classified as a vasoconstrictor used in the treatment of low blood pressure, particularly orthostatic hypo...

BPH715
(CAS: 1059677-23-4)

BPH715 is a new generation of lipophilic bisphosphonates. It is potent in cell culture and effectively inhibited tumor cell growth and invasiveness. It is used ...

CAS 66215-27-8 Cyromazine

Cyromazine
(CAS: 66215-27-8)

Cyromazine is a triazine insect growth regulator used as an insecticide and an acaricide.

CAS 107538-05-6 Dexmecamylamine

Dexmecamylamine
(CAS: 107538-05-6)

Dexmecamylamine is a nicotinic channel modulator with antidepressant activity. It demonstrated positive effects in a number of animal models of depression and a...

CAS 55-86-7 Mechlorethamine hydrochloride

Mechlorethamine hydrochloride
(CAS: 55-86-7)

Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication.

SID 3712249
(CAS: 522606-67-3)

SID 3712249 is an biogenesis of microRNA-544 (miR-544) inhibitor caused apoptosis in triple negative breast cancer cells.

CAS 939983-14-9 p53 and MDM2 proteins-interaction-inhibitor racemic

p53 and MDM2 proteins-interaction-inhibi
(CAS: 939983-14-9)

p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins.

CAS 68-19-9 Vitamin B12

Vitamin B12
(CAS: 68-19-9)

Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.

CAS 53936-56-4 Deoxyarbutin

Deoxyarbutin
(CAS: 53936-56-4)

DeoxyArbutin is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.

RO 5263397
(CAS: 1357266-05-7)

RO5263397 is a selective trace amine-associated receptor 1(TAAR1) agonist. TAAR1 is a drug discovery target for cocaine addiction. RO5263397 is efficacious in r...

CAS 23327-57-3 Nefopam Hydrochloride

Nefopam Hydrochloride
(CAS: 23327-57-3)

Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline...

CAS 4773-96-0 Mangiferin

Mangiferin
(CAS: 4773-96-0)

Mangiferin prevents the renal glomerulus fibrosis of diabetic rats, which is realized through the suppression of osteopontin overproduction and inflammation lik...

CAS 6020-18-4 Coptisine chloride

Coptisine chloride
(CAS: 6020-18-4)

Coptisine chloride, an alkaloid found in Chinese goldthread, can be absorbed across intestinal epithelial cells, and they are completely absorbed compounds.

ABT-20
(CAS: 309959-34-0)

ABT-202, a small molecule, asts as an agonist at neural nicotinic acetylcholine receptors.

CAS 17008-69-4 Pseudobufarenogin

Pseudobufarenogin
(CAS: 17008-69-4)

Pseudobufarenogin is a natural compound extracted from toad species with unknown details.

CAS 84573-16-0 Rocaglamide

Rocaglamide
(CAS: 84573-16-0)

Rocaglamide is the first cyclopenta[b]benzofuran derivative extracted from Aglaia elliptifolia in 1982 by King and colleagues. Its IC50 value is ~50 nM for the ...

Reference Reading


1.Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis.
Gonçalves-de-Albuquerque CF1, Medeiros-de-Moraes IM1, Oliveira FM1, Burth P2, Bozza PT1, Castro Faria MV3, Silva AR1, Castro-Faria-Neto HC1,4. PLoS One. 2016 Apr 14;11(4):e0153607. doi: 10.1371/journal.pone.0153607.
Sepsis is characterized by inflammatory and metabolic alterations, which lead to massive cytokine production, oxidative stress and organ dysfunction. In severe systemic inflammatory response syndrome, plasma non-esterified fatty acids (NEFA) are increased. Several NEFA are deleterious to cells, activate Toll-like receptors and inhibit Na+/K+-ATPase, causing lung injury. A Mediterranean diet rich in olive oil is beneficial. The main component of olive oil is omega-9 oleic acid (OA), a monounsaturated fatty acid (MUFA). We analyzed the effect of OA supplementation on sepsis. OA ameliorated clinical symptoms, increased the survival rate, prevented liver and kidney injury and decreased NEFA plasma levels in mice subjected to cecal ligation and puncture (CLP). OA did not alter food intake and weight gain but diminished reactive oxygen species (ROS) production and NEFA plasma levels. Carnitine palmitoyltransferase IA (CPT1A) mRNA levels were increased, while uncoupling protein 2 (UCP2) liver expression was enhanced in mice treated with OA.
2.Neurochemical Changes Associated with Stress-Induced Sleep Disturbance in Rats: In Vivo and In Vitro Measurements.
Lee DW1,2, Chung S3, Yoo HJ4, Kim SJ4, Woo CW2, Kim ST2, Lee DH1, Kim KW5, Kim JK5, Lee JS5, Choi CG5, Shim WH5, Choi Y2, Woo DC2. PLoS One. 2016 Apr 14;11(4):e0153346. doi: 10.1371/journal.pone.0153346.
The goal of this study was to quantitatively assess the changes in the cerebral neurochemical profile and to identify those factors that contribute to the alteration of endogenous biomolecules when rats are subjected to stress-induced sleep disturbance. We exposed Sprague-Dawley rats (controls: n = 9; stress-induced sleep perturbation rats: n = 11) to a psychological stressor (cage exchange method) to achieve stress-induced sleep perturbation. In vivo magnetic resonance imaging assessments were carried out using a high-resolution 9.4 T system. For in vivo neurochemical analysis, a single voxel was localized in the right dorsal hippocampal region, and in vivo spectra were quantified for 17 cerebral neurochemical signals. Rats were sacrificed upon completion of the magnetic resonance spectroscopy protocol, and whole-brain tissue was harvested from twenty subjects. The dopamine and serotonin signals were obtained by performing in vitro liquid chromatography-tandem mass spectrometry on the harvested tissue.
3.Orientation-Selective Alignments of Hydroxyapatite Nanoblocks through Epitaxial Attachment in a and c Directions.
Nakamura K1, Nakagawa Y1, Kageyama H1, Oaki Y1, Imai H1. Langmuir. 2016 Apr 14. [Epub ahead of print]
Nanometric rods of hydroxyapatite (HA) were aligned in selective crystallographic directions by the alternation of adsorbing molecules. The side and end faces of HA nanorods elongated in the c direction were covered with oleic acid (OA) and tetraoctylammonium (TOA) ions, respectively. Alignment in the c direction of the OA-modified nanorods was produced through epitaxial attachment of the bare end faces in toluene because the side faces were hydrophobized with the negatively charged modifier. Another alignment-in the a direction of the TOA-modified HA nanorods-was obtained through the epitaxial attachment of the bare side faces in ethanol due to stabilization of the end faces with the positively charged modifier. Controlled alignments of the nanorods in the a and c directions were achieved through oriented attachment with the selective coverage of the c and a faces with the specific modifiers.
4.Serum Uric Acid Is Positively Associated with Handgrip Strength among Japanese Community-Dwelling Elderly Women.
Kawamoto R1,2, Ninomiya D1,2, Kasai Y2, Kusunoki T2, Ohtsuka N2, Kumagi T1, Abe M1. PLoS One. 2016 Apr 14;11(4):e0151044. doi: 10.1371/journal.pone.0151044.
Serum uric acid (UA) has strong anti-oxidant properties. Muscle strength and mass decrease with age, and recently, this decrease has been defined as sarcopenia. Sarcopenia may be triggered by oxidative stress. We investigated whether serum UA is associated with handgrip strength (HGS), which is a useful indicator of sarcopenia, among Japanese community-dwelling elderly persons. The present study included 602 men aged 72 ± 7 years and 847 women aged 71 ± 6 years from a rural village. We examined the cross-sectional relationship between serum UA and HGS. In both genders, HGS increased significantly with increased serum UA levels. A multiple linear regression analysis using HGS as an objective variable and various confounding factors as explanatory variables showed that in men age, drinking status, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and estimated glomerular filtration ratio (eGFRCKDEPI) were independently and significantly associated with HGS, and in women, serum UA as well as age, body mass index, drinking status, diastolic blood pressure, and eGFRCKDEPI were independently and significantly associated with HGS.