4-(PIPERAZIN-1-YLMETHYL)BENZOIC ACID - CAS 220213-15-0
Catalog number:
220213-15-0
Category:
Main Product
Molecular Formula:
C12H16N2O2
Molecular Weight:
220.27
COA:
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Purity:
97+%
Synonyms:
RARECHEM AL BO 1043; 4-(PIPERAZIN-1-YLMETHYL)BENZOIC ACID; 4-(1-Piperazinylmethyl)-benzoic acid
MSDS:
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Boiling Point:
386.094ºC at 760 mmHg
Density:
1.195g/cm3
InChIKey:
PNRGRAZXFRLSJE-UHFFFAOYSA-N
InChI:
InChI=1S/C12H16N2O2/c15-12(16)11-3-1-10(2-4-11)9-14-7-5-13-6-8-14/h1-4,13H,5-9H2,(H,15,16)
Canonical SMILES:
C1CN(CCN1)CC2=CC=C(C=C2)C(=O)O
1.Identification of imatinib mesylate degradation products obtained under stress conditions.
Szczepek WJ1, Kosmacińska B, Bielejewska A, Łuniewski W, Skarzyński M, Rozmarynowska D. J Pharm Biomed Anal. 2007 Apr 11;43(5):1682-91. Epub 2007 Jan 12.
In this paper, the decomposition of imatinib mesylate (ImM) under hydrolytic (neutral, acidic, alkaline), oxidative and photolytic conditions was studied. The imatinib mesylate is practically photostable and stable under neutral conditions. The main degradation products under acidic and alkaline conditions are compounds: 4-methyl-N3-(4-pyridin-3-yl-pyrimidyn-2-yl)-benzene-1,3-diamine (2) and 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid (3). The main degradation products under oxidation conditions, i.e. 4-[(4-methyl-4-oxido-piperazin-1-yl)-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide (6), 4-[(4-methyl-1-oxido-piperazin-1-yl)-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide (7) and 4-[(4-methyl-1,4-dioxido-piperazin-1-yl)-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide (8), were isolated from the reaction mixtures and identified by the HPLC, 1H NMR and MS techniques.
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CAS 220213-15-0 4-(PIPERAZIN-1-YLMETHYL)BENZOIC ACID

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