4-(PIPERAZIN-1-YLMETHYL)BENZOIC ACID - CAS 220213-15-0
Category:
Main Product
Product Name:
4-(PIPERAZIN-1-YLMETHYL)BENZOIC ACID
Catalog Number:
220213-15-0
Synonyms:
RARECHEM AL BO 1043; 4-(PIPERAZIN-1-YLMETHYL)BENZOIC ACID; 4-(1-Piperazinylmethyl)-benzoic acid
CAS Number:
220213-15-0
Molecular Weight:
220.27
Molecular Formula:
C12H16N2O2
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
C1CN(CCN1)CC2=CC=C(C=C2)C(=O)O
InChI:
InChI=1S/C12H16N2O2/c15-12(16)11-3-1-10(2-4-11)9-14-7-5-13-6-8-14/h1-4,13H,5-9H2,(H,15,16)
InChIKey:
PNRGRAZXFRLSJE-UHFFFAOYSA-N
Chemical Structure
CAS 220213-15-0 4-(PIPERAZIN-1-YLMETHYL)BENZOIC ACID

Reference Reading


1.Identification of imatinib mesylate degradation products obtained under stress conditions.
Szczepek WJ1, Kosmacińska B, Bielejewska A, Łuniewski W, Skarzyński M, Rozmarynowska D. J Pharm Biomed Anal. 2007 Apr 11;43(5):1682-91. Epub 2007 Jan 12.
In this paper, the decomposition of imatinib mesylate (ImM) under hydrolytic (neutral, acidic, alkaline), oxidative and photolytic conditions was studied. The imatinib mesylate is practically photostable and stable under neutral conditions. The main degradation products under acidic and alkaline conditions are compounds: 4-methyl-N3-(4-pyridin-3-yl-pyrimidyn-2-yl)-benzene-1,3-diamine (2) and 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid (3). The main degradation products under oxidation conditions, i.e. 4-[(4-methyl-4-oxido-piperazin-1-yl)-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide (6), 4-[(4-methyl-1-oxido-piperazin-1-yl)-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide (7) and 4-[(4-methyl-1,4-dioxido-piperazin-1-yl)-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide (8), were isolated from the reaction mixtures and identified by the HPLC, 1H NMR and MS techniques.