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4-(PIPERAZIN-1-YLMETHYL)BENZOIC ACID - CAS 220213-15-0

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Category
Main Product
Product Name
4-(PIPERAZIN-1-YLMETHYL)BENZOIC ACID
Catalog Number
220213-15-0
Synonyms
RARECHEM AL BO 1043;4-(PIPERAZIN-1-YLMETHYL)BENZOIC ACID;4-(1-Piperazinylmethyl)-benzoic acid
CAS Number
220213-15-0
Molecular Weight
220.27
Molecular Formula
C12H16N2O2
COA
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MSDS
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Canonical SMILES
C1CN(CCN1)CC2=CC=C(C=C2)C(=O)O
InChI
InChI=1S/C12H16N2O2/c15-12(16)11-3-1-10(2-4-11)9-14-7-5-13-6-8-14/h1-4,13H,5-9H2,(H,15,16)
InChIKey
PNRGRAZXFRLSJE-UHFFFAOYSA-N
Structure
CAS 220213-15-0 4-(PIPERAZIN-1-YLMETHYL)BENZOIC ACID
Specification
Purity
97+%
Boiling Point
386.094ºC at 760 mmHg
Density
1.195g/cm3
Reference Reading
1.Identification of imatinib mesylate degradation products obtained under stress conditions.
Szczepek WJ1, Kosmacińska B, Bielejewska A, Łuniewski W, Skarzyński M, Rozmarynowska D. J Pharm Biomed Anal. 2007 Apr 11;43(5):1682-91. Epub 2007 Jan 12.
In this paper, the decomposition of imatinib mesylate (ImM) under hydrolytic (neutral, acidic, alkaline), oxidative and photolytic conditions was studied. The imatinib mesylate is practically photostable and stable under neutral conditions. The main degradation products under acidic and alkaline conditions are compounds: 4-methyl-N3-(4-pyridin-3-yl-pyrimidyn-2-yl)-benzene-1,3-diamine (2) and 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid (3). The main degradation products under oxidation conditions, i.e. 4-[(4-methyl-4-oxido-piperazin-1-yl)-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide (6), 4-[(4-methyl-1-oxido-piperazin-1-yl)-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide (7) and 4-[(4-methyl-1,4-dioxido-piperazin-1-yl)-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide (8), were isolated from the reaction mixtures and identified by the HPLC, 1H NMR and MS techniques.
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