4'-Hydroxyphenyl carvedilol - CAS 142227-49-4
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
4'-Hydroxyphenyl carvedilol
Catalog Number:
142227-49-4
Synonyms:
(R)-(+)-4'-HYDROXYPHENYL-CARVEDILOL;(S)-(-)-4'-HYDROXYPHENYL-CARVEDILOL;(R)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol;(R)-4-Hydroxycarvedilol;(R)-BM 140686;(R)-BM 14686;(S)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl
CAS Number:
142227-49-4
Description:
4'-Hydroxyphenyl carvedilol, as a metabolite of Carvedilol it is a nonselective beta blocker/alpha-1 blocker.
Molecular Weight:
422.47
Molecular Formula:
C24H26N2O5
Quantity:
Grams-Kilos
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=N4)C5CCOCC5)C(C)COC)OC
InChI:
1S/C25H30N4O4/c1-14(13-30-4)29-24-18-11-22(31-5)19(23-15(2)28-33-16(23)3)10-20(18)26-12-21(24)27-25(29)17-6-8-32-9-7-17/h10-12,14,17H,6-9,13H2,1-5H3/t14-/m1/s1
InChIKey:
HYPXHDJBILNWLI-CQSZACIVSA-N
Targets:
Others
Chemical Structure
CAS 142227-49-4 4'-Hydroxyphenyl carvedilol

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Reference Reading


1.Inhibitory effect of ketoconazole and voriconazole on the pharmacokinetics of carvedilol in rats.
Wang L1, Wang S2, Chen M1, Chen X1, Lin Y1, Hu X1, Huang X1, Li X1, Hu G1. Drug Dev Ind Pharm. 2015;41(10):1661-6. doi: 10.3109/03639045.2014.983930. Epub 2014 Nov 24.
The aim of this study was to investigate the effect of orally administered ketoconazole and voriconazole on the pharmacokinetics of carvedilol and its metabolites in rats. Fifteen healthy male Sprague-Dawley (SD) rats were randomly divided into three groups: A group (30 mg/kg ketoconazole), B group (30 mg/kg voriconazole) and C group (control group). A single dose of carvedilol was administered orally 30 min after administration of ketoconazole and voriconazole. Carvedilol and its metabolites plasma levels were measured by ultra-high performance liquid chromatography-mass spectrometry method (UPLC-MS/MS), and pharmacokinetic parameters were calculated by DAS 3.0 software. The co-administrated with ketoconazole could significantly increase the maximal plasma concentration (Cmax) and area under the curve (AUC) of carvedilol (p < 0.01). And the Cmax of its three metabolites 4'-hydroxyphenyl carvedilol (4'-HPC), 5'-hydroxyphenyl carvedilol (5'-HPC) and o-desmethyl carvedilol (o-DMC) decreased drastically by 39.
2.Simultaneous quantification of carvedilol and its metabolites in rat plasma by ultra performance liquid chromatography tandem mass spectrometry and pharmacokinetic application.
Li J1, Wang L1, Wang S2, Chen M1, Gu E1, Hu G1, Ge R3. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 1;974:138-46. doi: 10.1016/j.jchromb.2014.10.037. Epub 2014 Nov 4.
A rapid-resolution ultra high-performance liquid chromatography-tandem mass spectrometry separation method (UPLC-MS/MS) was developed for the simultaneous determination of carvedilol, and its three metabolites: 4'-hydroxyphenyl-carvedilol, 5'-hydroxyphenyl-carvedilol, o-desmethyl-carvedilol. The effective UPLC-MS/MS separation of the examined compounds was applied on an Acquity BEH C18 column (2.1 mm × 5 0 mm, 1.7 μm particle size) column with a gradient mobile phase system. The analysis was performed in less than 6 min with a flow rate of 0.4 mL/min. The assay was validated over concentration ranges of 0.500-100 ng/mL for carvedilol and 0.0500-10.0 ng/mL for its three metabolites. Intra- and inter-assay precision values for replicate quality control samples were within 11.4% for all analytes during the assay validation. Mean quality control accuracy values were within ±11.5% of nominal values for all analytes. Assay recoveries were high (>91%) and internal standard normalized matrix effects were minimal.
3.A validated enantioselective LC-MS/MS assay for the simultaneous determination of carvedilol and its pharmacologically active 4'-hydroxyphenyl
Furlong MT1, He B, Mylott W, Zhao S, Mariannino T, Shen J, Stouffer B. J Pharm Biomed Anal. 2012 Nov;70:574-9. doi: 10.1016/j.jpba.2012.05.026. Epub 2012 May 30.
Carvedilol is widely prescribed for the treatment of hypertension, heart failure and left ventricular dysfunction following myocardial infarction. A sensitive and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was developed and validated to enable reliable and efficient bioanalysis of the (R)- and (S)-enantiomers of carvedilol and its pharmacologically active 4'-hydroxyphenyl metabolite in human plasma. Following plasma extraction using supported liquid extraction (SLE) in a 96-well plate format, extracted samples were derivatized with 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate (GITC). Chromatographic separation was achieved by gradient elution on an ACQUITY UPLC HSS T3 analytical column. The impact of several potentially interfering isobaric metabolites on the quantification of the 4'-hydroxyphenyl metabolite (R)- and (S)-enantiomers was minimized by implementation of a combination of chromatographic and mass spectrometric techniques.
4.The Effect of Apatinib on the Metabolism of Carvedilol Both in vitro and in vivo.
Lin D1, Wang Z, Li J, Wang L, Wang S, Hu GX, Liu X. Pharmacology. 2016;97(1-2):31-7. doi: 10.1159/000441228. Epub 2015 Nov 17.
BACKGROUND: In light of the growing number of cancer survivors, the incidence of cardiovascular complications in these patients had also increased, while the effect of apatinib on the pharmacokinetic of cardioprotective drug (carvedilol) in rats or human is still unknown. The present work was to study the impact of apatinib on the metabolism of carvedilol both in vitro and vivo.