4-Chloro-3,5-dimethylphenol - CAS 88-04-0
Not Intended for Therapeutic Use. For research use only.
Product Name:
Catalog Number:
PCMX;2-Chloro-m-xylenol;3,5-Xylenol, 4-chloro-;4-Chloro-1-hydroxy-3,5-dimethylbenzene;4-Chloro-3-xylenol;Chloroxylenol;4-Chloro-3,5-xylenol;Dettol;Benzytol
CAS Number:
4-Chloro-3,5-dimethylphenol is a chemical compound which has antimicrobial effect due to disruption of cell membrane potentials. lt is an antiseptic and germicide. It is mainly used to control bacteria, algae, fungi and virus and is used in hospitals and households for disinfection and sanitation. lt is also used in antibacterial soaps, wound-cleansing applications and household antiseptics. lt is not significantly toxic to humans, moderately toxic to freshwater invertebrates and practically non-toxic to birds. But it is highly toxic to fish and cats. It is a mild skin irritant and may trigger allergic reactions in some individuals.
Molecular Weight:
Molecular Formula:
Kilogram to ton
Quality Standard:
In-house standard
Canonical SMILES:
Chemical Structure
CAS 88-04-0 4-Chloro-3,5-dimethylphenol

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Reference Reading

1.[Determination of 4-chloro-3,5-dimethyl phenol in antiseptics and synthetic products by scanning thin-layer chromatography].
Cao XF1, Zhang SW, Li YH, Liu JC, Tong JB. Se Pu. 2001 Jul;19(4):356-7.
A new method of scanning thin-layer chromatography was established for the quantitative determination of the 4-chloro-3,5-dimethyl phenol by developing with 40% benzene in trichloromethane on GF254 silica gel plate. The results showed that the linear dynamic range of 4-chloro-3, 5-dimethyl phenol was 0.1858 g/L-7.4320 g/L in which the relative peak area obeyed the Lambert-Beer's law with a correlation coefficient of 0.9994 and recoveries of 98.31%-100.1%. The method is simple, rapid, sensitive and reproducible.
2.Mineralization of the biocide chloroxylenol by electrochemical advanced oxidation processes.
Skoumal M1, Arias C, Cabot PL, Centellas F, Garrido JA, Rodríguez RM, Brillas E. Chemosphere. 2008 Apr;71(9):1718-29. doi: 10.1016/j.chemosphere.2007.12.029. Epub 2008 Feb 11.
Electrochemical advanced oxidation processes (EAOPs) are environmentally friendly methods based on the destruction of organic pollutants in wastewaters with in situ electrogenerated hydroxyl radical. This species is formed in anodic oxidation (AO) from water oxidation at the anode and in indirect electro-oxidation methods like electro-Fenton (EF) and photoelectro-Fenton (PEF) also from reaction between catalytic Fe2+ and H2O2 continuously produced at the O2-diffusion cathode. The PEF method involves the irradiation of the treated solution with UVA light to enhance the photolysis of organics including Fe(III) complexes. In this work, the oxidation power of such EAOPs to decontaminate synthetic wastewaters of the biocide chloroxylenol (4-chloro-3,5-dimethylphenol) at pH 3.0 is comparatively examined with an undivided electrolytic cell containing a Pt or boron-doped diamond (BDD) anode and a stainless steel or O2-diffusion cathode. The initial chlorine is released as Cl(-) ion, which remains stable in the medium using Pt or is oxidized to Cl2 on BDD.
3.Evaluation of estrogenic activity of organic biocides using ER-binding and YES assay.
Nakama A1, Funasaka K, Shimizu M. Food Chem Toxicol. 2007 Sep;45(9):1558-64. Epub 2007 Feb 21.
Biocides have been used not only in everyday items such as clothes, kitchenware, daily necessities, and infant utensils, but also in cosmetics and wrapping papers for foodstuffs. Since there is a high possibility of exposure to biocides from such materials, their safety must be assessed adequately using a range of methods. We investigated the estrogenic activity of 20 organic biocides using two in vitro screen assays: estrogen receptor (ER) binding assay and yeast estrogen screen (YES) assay. Twelve of the biocides were positive in the ER-binding assay. Regardless of the presence or absence of rat S9Mix for metabolic activation, 4-chloro-3-methylphenol was positive in both ER-binding and YES assay. 4-Chloro-3,5-dimethylphenol was positive in the ER-binding assay and showed a pseudopositive manner in the YES assay that was observed the dose-independent estrogenic activity at only one dose point. Hiba oil was positive in the ER-binding assay but was positive in the YES assay only in the presence of rat S9Mix.
4.Degradation of 4-Chloro-3,5-Dimethylphenol by a Heterogeneous Fenton-Like Reaction Using Nanoscale Zero-Valent Iron Catalysts.
Xu L1, Wang J. Environ Eng Sci. 2013 Jun;30(6):294-301.
Degradation of 4-chloro-3,5-dimethylphenol (PCMX) by a heterogeneous Fenton-like process using nanoparticulate zero-valent iron (nZVI) and hydrogen peroxide (H2O2) at pH 6.3 was investigated. Interactive effects of three factors-initial PCMX concentration, nZVI dosage, and H2O2 concentration-were investigated using the response surface method based on the Box-Behnken design. Experimental results showed that complete decomposition of PCMX and 65% of total organic carbon removal were observed after 30 min of reaction at neutral pH under recommended reaction conditions: nZVI, 1.0 g/L; H2O2, 18 mM; and initial PCMX concentration, 0.15 g/L. Based on the effects of scavengers n-butanol and KI, removal of PCMX was mainly attributed to the attack of •OH, especially the surface-bonded •OH. A possible degradation pathway of PCMX was proposed.