4-Aminobenzoic Acid - CAS 150-13-0
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
4-Aminobenzoic Acid
Catalog Number:
150-13-0
Synonyms:
4-aminobenzoic acid 4 Aminobenzoic Acid 4 Aminobenzoic Acid, Potassium Salt 4-Aminobenzoate, Potassium 4-Aminobenzoic Acid 4-Aminobenzoic Acid, Potassium Salt Aminobenzoate, Potassium Aminobenzoic Acid (USP) Epit Vit Epitelplast Glenwood brand of Potassiu
CAS Number:
150-13-0
Description:
4-Aminobenzoic Acid, also called as PABA, was used as sunscreening agent at the past due to its UV absorption and antifibrotic properties.
Molecular Weight:
137.14
Molecular Formula:
C7H7NO2
Quantity:
Grams-Kilos
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
C1=CC(=CC=C1C(=O)O)N
InChI:
1S/C7H7NO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H,9,10)
InChIKey:
ALYNCZNDIQEVRV-UHFFFAOYSA-N
Targets:
Others
Chemical Structure
CAS 150-13-0 4-Aminobenzoic Acid

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Reference Reading


1.Gold nanostar-enhanced surface plasmon resonance biosensor based on carboxyl-functionalized graphene oxide.
Wu Q1, Sun Y1, Ma P1, Zhang D1, Li S1, Wang X1, Song D2. Anal Chim Acta. 2016 Mar 24;913:137-44. doi: 10.1016/j.aca.2016.01.063. Epub 2016 Feb 4.
A new high-sensitivity surface plasmon resonance (SPR) biosensor based on biofunctional gold nanostars (AuNSs) and carboxyl-functionalized graphene oxide (cGO) sheets was described. Compared with spherical gold nanoparticles (AuNPs), the anisotropic structure of AuNSs, which concentrates the electric charge density on its sharp tips, could enhance the local electromagnetic field and the electronic coupling effect significantly. cGO was obtained by a diazonium reaction of graphene oxide (GO) with 4-aminobenzoic acid. Compared with GO, cGO could immobilize more antibodies due to the abundant carboxylic groups on its surface. Testing results show that there are fairly large improvements in the analytical performance of the SPR biosensor using cGO/AuNSs-antigen conjugate, and the detection limit of the proposed biosensor is 0.0375 μg mL(-1), which is 32 times lower than that of graphene oxide-based biosensor.
2.Electrochemical immunosensor for ethinylestradiol using diazonium salt grafting onto silver nanoparticles-silica-graphene oxide hybrids.
Cincotto FH1, Martínez-García G2, Yáñez-Sedeño P2, Canevari TC3, Machado SA1, Pingarrón JM2. Talanta. 2016 Jan 15;147:328-34. doi: 10.1016/j.talanta.2015.09.061. Epub 2015 Oct 1.
This work describes the preparation of an electrochemical immunosensor for ethinylestradiol (EE2) based on grafting of diazonium salt of 4-aminobenzoic acid onto a glassy carbon electrode modified with silver nanoparticles/SiO2/graphene oxide hybrid followed by covalent binding of anti-ethinylestradiol (anti-EE2) to activated carboxyl groups. A competitive immunoassay was developed for the determination of the hormone using peroxidase-labeled ethinylestradiol (HRP-EE2) and measurement of the amperometric response at -200mV in the presence of hydroquinone (HQ) as redox mediator. The calibration curve for EE2 exhibited a linear range between 0.1 and 50ng/mL (r(2)=0.996), with a detection limit of 65pg/mL. Interference studies with other hormones related with EE2 revealed the practical specificity of the developed method for the analyte. A good reproducibility, with RSD=4.5% (n=10) was also observed. The operating stability of a single bioelectrode modified with anti-EE2 was maintained at least for 15 days when it was stored at 4°C under humid conditions between measurements.
3.Mediatorless solar energy conversion by covalently bonded thylakoid monolayer on the glassy carbon electrode.
Lee J1, Im J1, Kim S2. Bioelectrochemistry. 2016 Apr;108:21-7. doi: 10.1016/j.bioelechem.2015.11.003. Epub 2015 Nov 28.
Light reactions of photosynthesis that take place in thylakoid membranes found in plants or cyanobacteria are among the most effective ways of utilizing light. Unlike most researches that use photosystem I or photosystem II as conversion units for converting light to electricity, we have developed a simple method in which the thylakoid monolayer was covalently immobilized on the glassy carbon electrode surface. The activity of isolated thylakoid membrane was confirmed by measuring evolving oxygen under illumination. Glassy carbon surfaces were first modified with partial or full monolayers of carboxyphenyl groups by reductive C-C coupling using 4-aminobenzoic acid and aniline and then thylakoid membrane was bioconjugated through the peptide bond between amine residues of thylakoid and carboxyl groups on the surface. Surface properties of modified surfaces were characterized by cyclic voltammetry, contact angle measurements, and electrochemical impedance spectroscopy.
4.Inhibition of myeloperoxidase activity have impact on the formation of DNA double-strand breaks induced by etoposide in HL-60 cell line.
Papież MA1, Krzyściak W, Wąsik M. Folia Med Cracov. 2015;55(1):43-51.
Many studies have shown the role of myeloperoxidase (MPO) in leukemogenic activity of etoposide. The aim of our study was to determine whether inhibition of MPO activity has influence on the formation of double-stranded DNA breaks (DSBs) that may contribute to the characteristic of leukemia translocations. Studies were carried out on HL-60 cell line, which were preincubated with the MPO inhibitor 4-aminobenzoic acid hydrazide (ABAH), or antioxidant N-acetyl-L-cysteine (NAC), followed by incubation at different concentrations of etoposide (1-10 mM) for 4 hours. Cytotoxicity was investigated using propidium iodide staining. Marker of DSBs, a phosphorylated form of histone 2AX (gH2AX) was detected using immunocytochemical methods. Cells were analyzed by flow cytometry. ABAH significantly reduced the cytotoxicity and the gH2AX level induced by lower concentrations of etoposide (1 and 1.5 mM) and did not modify the action of higher concentration (10 mM) of this cytostatic drug.