4-(2-Methoxy- benzenesulfonyl) -piperazine hydrochloride - CAS 864759-55-7

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Category
Main Product
Product Name
4-(2-Methoxy- benzenesulfonyl) -piperazine hydrochloride
Catalog Number
864759-55-7
Synonyms
4-(2-METHOXY-BENZENESULFONYL)-PIPERAZINE HYDROCHLORIDE; 4-(2-Methoxy-benzenesulfonyl)-piperazine hydrochloride >99% pure
CAS Number
864759-55-7
Molecular Weight
292.78
Molecular Formula
C11H17ClN2O3S
COA
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MSDS
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Structure
CAS 864759-55-7 4-(2-Methoxy- benzenesulfonyl) -piperazine hydrochloride
Specification
Purity
95%
Reference Reading
1.Synthesis and the biological evaluation of 2-benzenesulfonylalkyl-5-substituted-sulfanyl-[1,3,4]-oxadiazoles as potential anti-hepatitis B virus agents.
Tan TM1, Chen Y, Kong KH, Bai J, Li Y, Lim SG, Ang TH, Lam Y. Antiviral Res. 2006 Aug;71(1):7-14. Epub 2006 Mar 9.
Current treatments for chronic hepatitis B virus (HBV) infection include the use of interferon-alpha and of nucleoside analogs lamivudine, adefovir and entecavir. However, the use of interferon-alpha has many side effects while that of nucleosidic inhibitors can lead to the emergence of resistant viruses. Hence, new drugs for the treatment of HBV infection are still highly desired. Oxadiazoles have been observed to exhibit antiviral activities against RNA viruses. In this study, a facile synthesis of 2-benzenesulfonylalkyl-5-substituted-sulfanyl-[1,3,4]-oxadiazoles is reported. The compounds were then evaluated for their anti-HBV activity. 1-[2-[5-(1-Benzenesulfonyl-propyl)-[1,3,4]oxadiazol-2-yl-sulfanyl]-ethyl]-4-(2-methoxy-phenyl)-piperazine (1i) was able to inhibit the expression of the viral antigens, HBsAg and HBeAg in a concentration-dependent manner with no cytotoxic effects and without any effects on the expression of viral transcripts.
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