3-Hydroxy-4-trifluoromethyl pyridine - CAS 936841-71-3

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Main Product
Product Name
3-Hydroxy-4-trifluoromethyl pyridine
Catalog Number
3-Hydroxy-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)pyridin-3-ol
CAS Number
Molecular Weight
Molecular Formula
CAS 936841-71-3 3-Hydroxy-4-trifluoromethyl pyridine
Boiling Point
290.3ºC at 760 mmHg
Reference Reading
1.Discovery of a Potent, Selective, Orally Bioavailable and Efficacious Novel 2-(pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).
Degorce SL, Boyd S, Curwen JO, Ducray R, Halsall CT, Jones CD, Lach F, Lenz EM, Pass M, Pass S, Trigwell CB. J Med Chem. 2016 Apr 14. [Epub ahead of print]
Optimization of cellular lipophilic ligand efficiency (LLE) in a series of 2-anilino-pyrimidine IGF-1R kinase inhibitors led to the identification of novel 2-(pyrazol-4-ylamino)-pyrimidines with improved physico-chemical properties. Replacement of the imidazo[1,2-a]pyridine group of the previously reported inhibitor 3 with the related pyrazolo[1,5-a]pyridine improved IGF-1R cellular potency. Substitution of the amino-pyrazole group was key to obtaining excellent kinase selectivity and pharmacokinetic parameters suitable for oral dosing, which led to the discovery of (2R)-1-[4-(4-{[5-Chloro-4-(pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinyl]amino}-3,5-dimethyl-1H-pyrazol-1-yl)-1-piperidinyl]-2-hydroxy-1-propanone (AZD9362, 28), a novel, efficacious inhibitor of IGF-1R.
2.Fluorescence, Photophysical Behaviour and DFT Investigation of E,E-2,5-bis[2-(3-pyridyl)ethenyl]pyrazine (BPEP).
Al-Soliemy AM1, Osman OI1,2, Hussein MA1,3, Asiri AM4,5, El-Daly SA6,7. J Fluoresc. 2016 Apr 15. [Epub ahead of print]
E,E-2,5-bis[2-(3-pyridyl)ethenyl]pyrazine (BPEP) has been prepared by aldol condensation between 2,5-dimethylpyrazine and pyridine-3-carboxaldehyde. It is characterized by IR, 1H NMR, and 13C NMR. The electronic absorption and emission properties of BPEP were studied in different solvents. BPEP displays a slight solvatochromic effect of the absorption and emission spectrum, indicating a small change in dipole moment of BPEP upon excitation. The dye solutions (1 × 10-4 M) in CHCl3, EtOH and dioxane give laser emission in blue region upon excitation by a 337.1 nm nitrogen pulse (λ = 337 nm). The tuning range, gain coefficient (α) and emission cross - section (σe) have been determined. Ground and excited states electronic geometric optimizations were performed using density functional theory (DFT) and time-dependent density functional theory (TD-DFT), respectively. A DFT natural bond analysis complemented the ICT. The simulated maximum absorption and emission wavelengths are in line the observed ones in trend, and are proportionally red-shifted with the increase of the solvent polarity.
3.Synthesis, characterization, cytotoxicity and antiangiogenic activity of copper(II) complexes with 1-adamantoyl hydrazone bearing pyridine rings.
Rodić MV1, Leovac VM2, Jovanović LS1, Spasojević V3, Joksović MD4, Stanojković T5, Matić IZ5, Vojinović-Ješić LS1, Marković V4. Eur J Med Chem. 2016 Jun 10;115:75-81. doi: 10.1016/j.ejmech.2016.03.003. Epub 2016 Mar 8.
Three novel copper complexes with tridentate N2O ligand di(2-pyridil) ketone 1-adamantoyl hydrazone (Addpy) of the formula [Cu(II)2Cu(I)2(Addpy)2Br2(μ-Br4)] (1), catena-poly[CuCl(μ-Addpy)(μ-Cl)CuCl2]n (2) and [Cu(Addpy)(NCS)2] (3) were synthesized. Complexes are characterized by X-ray crystallography, spectral (UV-Vis, FTIR), electrochemical (CV) analyses, and magnetochemical measurements. Investigation of anticancer potential of Cu(II) complexes, mode of cell death, apoptosis, and inhibition of angiogenesis were performed. All tested malignant cell lines (HeLa, LS174, A549, K562, and MDA-MB-231) showed high sensitivity to the examined Cu(II) complexes. It has been shown that the complexes induce apoptosis in the caspase 3-dependent manner, whereas the anti-angiogenic effects of 1, 2, and 3 have been confirmed in EA.hy926 cells using a tube formation assay.
4.Acetylated cashew gum-based nanoparticles for transdermal delivery of diclofenac diethyl amine.
Dias SF1, Nogueira SS1, de França Dourado F1, Guimarães MA1, de Oliveira Pitombeira NA2, Gobbo GG3, Primo FL3, de Paula RC2, Feitosa JP2, Tedesco AC3, Nunes LC4, Leite JR1, da Silva DA5. Carbohydr Polym. 2016 Jun 5;143:254-61. doi: 10.1016/j.carbpol.2016.02.004. Epub 2016 Feb 3.
Nanoprecipitation and dialysis methods were employed to obtain nanoparticles (NPs) of acetylated cashew gum (ACG). NPs synthesized by dialysis showed greater average size compared to those synthesized by nanoprecipitation, but they presented improved stability and yield. NPs were loaded with diclofenac diethylamine and the efficiency of the drug incorporation was over 60% for both methods, for an ACG:NP a weight ratio of 10:1. The cytotoxicity assay demonstrated that the NPs had no significant effect on the cell viability, verifying their biocompatibility. The release profile for the diclofenac diethylamine associated with the ACG-NPs showed a more controlled release compared to the free drug and a Fickian diffusion mechanism was observed. Transdermal permeation reached 90% penetration of the drug.
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