(+/-)-3-AMINO-1-HYDROXY-2-PYRROLIDONE - CAS 70996-07-5
Category:
Main Product
Product Name:
(+/-)-3-AMINO-1-HYDROXY-2-PYRROLIDONE
Catalog Number:
70996-07-5
Synonyms:
(+/-)-HA-966; (+/-)-3-AMINO-1-HYDROXY-2-PYRROLIDONE; (3R)-1-Hydroxy-3-amino-2-pyrrolidone; (3R)-1-Hydroxy-3-aminopyrrolidine-2-one; [3R,(+)]-3-Amino-1-hydroxypyrrolidin-2-one
CAS Number:
70996-07-5
Molecular Weight:
116.12
Molecular Formula:
C4H8N2O2
COA:
Inquire
MSDS:
Inquire
Chemical Structure
CAS 70996-07-5 (+/-)-3-AMINO-1-HYDROXY-2-PYRROLIDONE

Reference Reading


1.Effects of glycine or (+/-)-3-amino-1-hydroxy-2-pyrrolidone microinjections along the rostrocaudal axis of the dorsal periaqueductal gray matter on rats' performance in the elevated plus-maze task.
Teixeira KV1, Carobrez AP. Behav Neurosci. 1999 Feb;113(1):196-203.
The effects of glycine (GLY) or (+/-)-3-amino-1-hydroxy-2-pyrrolidone (HA966), a GLY receptor antagonist, microinjections into sites along the rostrocaudal axis of the dorsal periaqueductal gray matter (dPAG) were studied in rats placed on the elevated plus maze (EPM). Selective alterations in the open-arm entries (OAEs) or open-arm time (OAT) of the EPM were the indexes of anxiety. HA966 (30 or 100 nmol, 0.3 microl) increased OAEs and OAT in all 3 dPAG sites, suggesting an anxiolytic effect. GLY (80 and 120 nmol, 0.3 microl) selectively reduced OAEs and OAT, suggesting an anxiogenic effect only when injections were given within the caudal dPAG. When administered together, HA966 reversed the anxiogenic effect of 120 nmol GLY, indicating pharmacological selectivity for the effects of GLY on GLY receptors. Results reinforce an involvement of N-Methyl-D-aspartate-coupled GLY receptors in anxiety and suggest that saturation of this receptor may vary along the dPAG.