Top Clicks This Month

3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole-3-14C, Acetate - CAS 210049-08-4

Quick Inquiry

Name:
* Email:
* Service & Products of Interest:
* Quantity:
* Verification code:
Please input "bocsci" as verification code.
Category
Main Product
Product Name
3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole-3-14C, Acetate
Catalog Number
210049-08-4
Synonyms
1,4-Dimethyl-5H-pyrido[4,3-b]indol-3-amine-3-14C Monoacetate;
CAS Number
210049-08-4
Molecular Weight
273.31
Molecular Formula
C1414CH17N3O2
COA
Inquire
MSDS
Inquire
Canonical SMILES
CC1=C(N=C(C2=C1NC3=CC=CC=C32)C)N.CC(=O)O
InChI
InChI=1S/C13H13N3.C2H4O2/c1-7-12-11(8(2)15-13(7)14)9-5-3-4-6-10(9)16-12;1-2(3)4/h3-6,16H,1-2H3,(H2,14,15);1H3,(H,3,4)/i13+2;
InChIKey
UXNRBAJNAWIPGF-BGRRMDFBSA-N
Structure
CAS 210049-08-4 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole-3-14C, Acetate
Specification
Purity
95%
Melting Point
250-260ºC
Appearance
Beige-Brown Crystalline Solid
Application
Trp-P-1 is highly mutagenic in the Ames test. Investigations have shown that broiled fish, fried beef and commercial beef extracts, and protein pyrolysates contain this mutagen.
Reference Reading
1.A hepatocarcinogenic tryptophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp1a2 in male mice.
Degawa M1, Hanaki K, Sekimoto M. Cancer Sci. 2006 Jan;97(1):32-7.
Male (BALB/c x DBA/2) F(1) mice were given 3-amino-1,4-dimethyl-5H-pyrido [4,3-b] indole acetate (Trp-P-1; 20 mg/kg body weight) by gavage at 24-h intervals for 1 or 2 weeks, and the effects of Trp-P-1 on the levels of serum total testosterone and hepatic cytochrome P4501a2 (Cyp1a2) were examined. A significant decrease in serum total testosterone level was observed after treatment with Trp-P-1 for 2 weeks, but not for 1 week. Likewise, gene expression levels of testicular androgenic enzymes, including cholesterol side chain cleavage cytochrome P450, 3beta-hydroxysteroid dehydrogenase and steroid 17alpha-hydroxylase/C17-20 lyase, decreased only in the mice treated with Trp-P-1 for 2 weeks. In contrast, levels of the mRNA and apoprotein of hepatic Cyp1a2 and its enzyme activity for O-demethylation of methoxyresorufin significantly increased in the mice treated with Trp-P-1 for 2 weeks, but only a small increase was observed in mice treated for 1 week.
2005 - BOC Sciences | All rights reserved
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE