1.MiR-23a regulate the vasculogenesis of coronary artery disease by targeting EGFR.
Wang S1, He W2, Wang C3. Cardiovasc Ther. 2016 Apr 17. doi: 10.1111/1755-5922.12187. [Epub ahead of print]
OBJECTIVE: Circulating microRNAs (miRNAs) in patient body fluids have recently been considered to hold the potential of being novel disease biomarkers and drug targets. We aimed to investigate the correlation between the levels of circulating miR-23a and the expression of epidermal growth factor receptor (EGFR) in the pathogenesis of coronary heart disease patients to further explore the mechanism involved in its vasculogenesis.
2.Association of AKR1C3 Polymorphisms with Bladder Cancer.
Tiryakioglu NO1, Tunali NE1. Urol J. 2016 Apr 16;13(2):2615-21.
PURPOSE: Polymorphisms in the genes coding for the carcinogen metabolizing enzymes may affect enzyme activities and alter the activation and detoxification rates of the carcinogens. AKR1C3 is one of the very polymorphic xenobiotic metabolizing enzymes involved in the bioactivation process. Here we aimed to investigate the association of two single nucleotide polymorphisms in AKR1C3, rs12529 (c.15C > G) and rs1937920 (12259 bp 3' of STP A > G) with urinary bladder cancer (UBC).
3.Vascular Endothelial-Cadherin Expression After Reperfusion Correlates With Lung Injury in Rat Lung Transplantation.
Tanaka S1, Chen-Yoshikawa TF1, Miyamoto E1, Takahashi M1, Ohata K1, Kondo T1, Hijiya K1, Motoyama H1, Aoyama A1, Date H2. Ann Thorac Surg. 2016 Apr 13. pii: S0003-4975(16)00052-7. doi: 10.1016/j.athoracsur.2016.01.040. [Epub ahead of print]
BACKGROUND: Vascular endothelial-cadherin (VEC), composing the adherens junction of endothelial cells, has been shown to regulate vascular permeability. The aim of this study was to investigate VEC expression during cold ischemia (CI) and reperfusion and whether a dibutyryl cyclic adenosine 3',5'-monophosphate (db-cAMP) and nitroglycerin (NTG) additive to preservation solution can maintain VEC.
4.Isolation and identification of oxidation products of syringol from brines and heated meat matrix.
Bölicke SM1, Ternes W2. Meat Sci. 2016 Apr 5;118:108-116. doi: 10.1016/j.meatsci.2016.03.029. [Epub ahead of print]
In this study we developed new extraction and detection methods (using HPLC-UV and LC-MS), making it possible to analyze the smoke phenol syringol and its oxidation products nitrososyringol, nitrosyringol, and the syringol dimer 3,3',5,5'-tetramethoxy-1,1'-biphenyl-4,4'-diol, which were identified in heated meat for the first time. Preliminary brine experiments performed with different concentrations of ascorbic acid showed that high amounts of this antioxidant also resulted in almost complete degradation of syringol and to formation of the oxidation products when the brines were heated at low pH values. Heat treatment (80°C) and subsequent simulated digestion applied to meat samples containing syringol, ascorbic acid and different concentrations of sodium nitrite produced 3,3',5,5'-tetramethoxy-1,1'-biphenyl-4,4'-diol even at a low nitrite level in the meat matrix, while nitroso- and nitrosyringol were isolated only after the digestion experiments.