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3,5-bis-(Trifluoromethyl)phenyl acetic acid methyl ester - CAS 95299-16-4

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Category
Main Product
Product Name
3,5-bis-(Trifluoromethyl)phenyl acetic acid methyl ester
Catalog Number
95299-16-4
CAS Number
95299-16-4
Molecular Weight
286.17
Molecular Formula
C11H8F6O2
COA
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MSDS
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Structure
CAS 95299-16-4 3,5-bis-(Trifluoromethyl)phenyl acetic acid methyl ester
Specification
Purity
95%
Boiling Point
199.074ºC at 760 mmHg
Density
1.367
Reference Reading
1.Synthesis and initial PET imaging of new potential NK1 receptor radioligands 1-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-4-[11C]methyl-piperazine and {4-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-piperazine-1-yl}-acetic acid [11C]methyl ester.
Gao M1, Mock BH, Hutchins GD, Zheng QH. Nucl Med Biol. 2005 Jul;32(5):543-52.
The NK(1) receptor radioligands 1-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-4-[(11)C]methyl-piperazine ([(11)C]BMP, [(11)C]) and {4-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-piperazine-1-yl}-acetic acid [(11)C]methyl ester ([(11)C]BME, [(11)C]) were synthesized for evaluation as new potential PET imaging agents for brain NK(1) receptors. The new tracers [(11)C]BMP and [(11)C]BME were prepared by N-[(11)C]methylation and O-[(11)C]methylation of corresponding precursors 1-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-piperazine and {4-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-piperazine-1-yl}-acetic acid using [(11)C]methyl triflate and isolated by solid-phase extraction (SPE) purification procedure with 40-55% radiochemical yields, decay corrected to end of bombardment, and a synthesis time of 15-20 min. The initial PET dynamic studies of the tracers [(11)C] and [(11)C] in rats were performed using an animal PET scanner, IndyPET-II, developed in our laboratory.
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