3,3,5-Triiodo-L-thyronine - CAS 6893-02-3
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
3,3,5-Triiodo-L-thyronine
Catalog Number:
6893-02-3
Synonyms:
O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T3
CAS Number:
6893-02-3
Description:
3,3,5-Triiodo-L-thyronine(T3), an active metabolite of Thyroxine, could be effective in agonizing both thyroid hormone receptors TRα and TRβ so that might help maintening the metabolic homeostasis. Kis = 2.3 nM for both α and β receptors.
Molecular Weight:
650.97
Molecular Formula:
C15H12I3NO4
Quantity:
Milligrams-Grams
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O
InChI:
InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
InChIKey:
AUYYCJSJGJYCDS-LBPRGKRZSA-N
Targets:
Others
Chemical Structure
CAS 6893-02-3 3,3,5-Triiodo-L-thyronine

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Reference Reading


1.3, 3',5-Triiodo-L-Thyronine Increases In Vitro Chondrogenesis of Mesenchymal Stem Cells from Human Umbilical Cord Stroma Through SRC2.
Fernández-Pernas P1, Fafián-Labora J1, Lesende-Rodriguez I1, Mateos J2, De la Fuente A1, Fuentes I1, De Toro J1, Blanco García F2, Arufe M1. J Cell Biochem. 2016 Feb 11. doi: 10.1002/jcb.25515. [Epub ahead of print]
OBJECTIVE: Our group focuses on the study of mesenchymal stem cells (MSCs) from human umbilical cord stroma or Warthon's jelly and their directed differentiation toward chondrocyte-like cells capable of regenerating damaged cartilage when transplanted into an injured joint. This study aimed to determine whether lactogenic hormone prolactin (PRL) or 3, 3', 5-triiodo-L-thyronine (T3), the active thyroid hormone, modulates chondrogenesis in our in vitro model of directed chondrogenic differentiation, and whether Wnt signalling is involved in this modulation.
2.Characterization of little skate (Leucoraja erinacea) recombinant transthyretin: Zinc-dependent 3,3',5-triiodo-l-thyronine binding.
Suzuki S1, Kasai K2, Yamauchi K3. Gen Comp Endocrinol. 2015 Jun-Jul;217-218:43-53. doi: 10.1016/j.ygcen.2015.04.006. Epub 2015 Apr 9.
Transthyretin (TTR) diverged from an ancestral 5-hydroxyisourate hydrolase (HIUHase) by gene duplication at some early stage of chordate evolution. To clarify how TTR had participated in the thyroid system as an extracellular thyroid hormone (TH) binding protein, TH binding properties of recombinant little skate Leucoraja erinacea TTR was investigated. At the amino acid level, skate TTR showed 37-46% identities with the other vertebrate TTRs. Because the skate TTR had a unique histidine-rich segment in the N-terminal region, it could be purified by Ni-affinity chromatography. The skate TTR was a 46-kDa homotetramer of 14.5kDa subunits, and had one order of magnitude higher affinity for 3,3',5-triiodo-l-thyronine (T3) and some halogenated phenols than for l-thyroxine. However, the skate TTR had no HIUHase activity. Ethylenediaminetetraacetic acid (EDTA) treatment inhibited [(125)I]T3 binding activity whereas the addition of Zn(2+) to the EDTA-treated TTR recovered [(125)I]T3 binding activity in a Zn(2+) concentration-dependent manner.
3.Anti-Apoptotic Effects of 3,3',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats.
Rebolledo RA1, Van Erp AC2, Ottens PJ2, Wiersema-Buist J2, Leuvenink HG2, Romanque P3. PLoS One. 2015 Oct 5;10(10):e0138749. doi: 10.1371/journal.pone.0138749. eCollection 2015.
BACKGROUND: Thyroid hormone treatment in brain-dead organ donors has been extensively studied and applied in the clinical setting. However, its clinical applicability remains controversial due to a varying degree of success and a lack of mechanistic understanding about the therapeutic effects of 3,3',5-Triiodo-L-thyronine (T3). T3 pre-conditioning leads to anti-apoptotic and pro-mitotic effects in liver tissue following ischemia/reperfusion injury. Therefore, we aimed to study the effects of T3 pre-conditioning in the liver of brain-dead rats.