27-Hydroxycholesterol - CAS 20380-11-4
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
27-Hydroxycholesterol
Catalog Number:
20380-11-4
Synonyms:
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-7-hydroxy-6-methyl-heptan-2-yl]-10,13-d;26-Hydroxycholesterol (not deuterated); 26-Hydroxycholesterol-26,26,27,27,27-D5; (25R)-Cholest-5-en-3β,26β-diol; (25R)-Cholest-5-ene-3β,26-diol;27-OHC; 5,25R-Cholesten-3beta,26-diol
CAS Number:
20380-11-4
Description:
27-Hydroxycholesterol, a desmosterol metabolite found in the brain , activates LXRα (EC50= 85 nM)and LXRβ (EC50= 71 nM) in vitro. 27-HC is also an estrogen receptor partial agonist. It suppresses β-estradiol-mediated breast cancer cell proliferation in vitro.
Molecular Weight:
402.65
Molecular Formula:
C27H46O2
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC(CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)CO
InChI:
1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKey:
FYHRJWMENCALJY-YSQMORBQSA-N
Targets:
LXR
Chemical Structure
CAS 20380-11-4 27-Hydroxycholesterol

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