2-Pyridin-2-ylethyl acetate - CAS 16632-09-0
Catalog number: 16632-09-0
Category: Main Product
Molecular Formula:
C9H11NO2
Molecular Weight:
165.19
COA:
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Purity:
95%
Synonyms:
2-PYRIDIN-2-YLETHYL ACETATE; Nsc25510
MSDS:
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Boiling Point:
242.6ºC at 760 mmHg
Density:
1.086 g/cm3
1.Hydrolysis of 4-nitrophenyl acetate by a (N2S(thiolate))zinc hydroxide complex: a model of the catalytically active intermediate for the zinc form of peptide deformylase.
diTargiani RC1, Chang S, Salter MH Jr, Hancock RD, Goldberg DP. Inorg Chem. 2003 Sep 22;42(19):5825-36.
A novel zinc(II) hydroxide complex with a rare alkylthiolate donor in the coordination sphere is formed in aqueous solution from the dissolution of the zinc alkyl precursor complex (PATH)ZnCH(3) (PATH = 2-methyl-1-[methyl(2-pyridin-2-ylethyl)amino]propane-2-thiolate) in H(2)O and protonolysis of the Zn-C bond to give (PATH)ZnOH (1). The (PATH)ZnOH complex has been shown to promote the hydrolysis of 4-nitrophenyl acetate (4-NA) by a detailed kinetic study and is the first functional model for the zinc form of the enzyme peptide deformylase. From a fit of the sigmoidal pH-rate profile a kinetic pK(a) of 8.05(5) and a pH-independent second-order rate constant (k" max)) of 0.089(3) M(-1) s(-1) have been obtained. The kinetic pK(a) is similar to the pK(a) of 7.7(1) determined by a potentiometric study (25 degrees C, I = 0.1 (NaNO3)). Observation of both rate enhancement and turnover shows that 1 acts as a catalyst for the hydrolysis of 4-NA, although the turnovers are modest.
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CAS 16632-09-0 2-Pyridin-2-ylethyl acetate

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