2 - nitro -3-- methoxybenzoic acid - CAS 4920-80-3
Category:
Main Product
Product Name:
2 - nitro -3-- methoxybenzoic acid
Catalog Number:
4920-80-3
Synonyms:
RARECHEM AL BE 0677; 3-METHOXY-2-NITROBENZOIC ACID; 2-NITRO-3-METHOXYBENZOIC ACID; 2-NITRO-M-ANISIC ACID; Benzoic acid, 3-methoxy-2-nitro-; m-Anisic acid, 2-nitro-
CAS Number:
4920-80-3
Molecular Weight:
197.14
Molecular Formula:
C8H7NO5
Quantity:
Data not available, please inquire.
COA:
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MSDS:
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Canonical SMILES:
COC1=CC=CC(=C1[N+](=O)[O-])C(=O)O
InChI:
InChI=1S/C8H7NO5/c1-14-6-4-2-3-5(8(10)11)7(6)9(12)13/h2-4H,1H3,(H,10,11)
InChIKey:
YMOMYSDAOXOCID-UHFFFAOYSA-N
Chemical Structure
CAS 4920-80-3 2 - nitro -3-- methoxybenzoic acid

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Reference Reading


1.[Studies on substances with antiblastic activity. IX. Anthramycin and analogs. IX. Synthesis of 7-methoxy-8-hydroxy-10,11-dihydro-5H-pyrrolo[2,1-c] [1,4] benzodiazepine and other compounds related t
Scalzo M, Artico M, Giuliano R, Chimenti F, Vomero S, Nacci V. Farmaco Sci. 1977 Aug;32(8):579-92.
The synthesis of some pyrrolobenzodiazepine derivatives related to oxotomaymycin, an antibiotic recovered together with tomaymycin from fermentation broths of Streptomyces achromogenes var. tomaymycetics, is described. Reaction between 2-nitro-4-benzyloxy-5-methoxybenzylbromide and pyrrole-2-carboxyaldehyde afforded 1-(2-nitro-4-benzyloxy-5-methoxybenzyl)pyrrole-2-carboxyaldehyde. Catalytic reduction of this compound with hydrogen in the presence of Pd/C gave 10,11-dihydro-8-hydroxy-7-methoxy-5H-pyrrolo[2.1-c] [1,4]benzodiazepine. Amides obtained from condensation between 2-nitro-4-benzyloxy-5-methoxybenzoic acid chloride and proline or hydroxyproline were reduced catalytically to 2,3-dihydro-8-hydroxy-7-methoxy-1H-pyrrolo [2,1-c] [1,4]benzodiazepine-5,11 (10H, 11aH)-dione and its 2-hydroxyderivative respectively. The synthesis of 10,11-dihydro-8-hydroxy-9-methoxy-5-pyrrolo [2,1-c] [1,4]benzodiazepine is also reported.