2-Methyl-2,4-pentanediol - CAS 107-41-5
Not Intended for Therapeutic Use. For research use only.
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2-Methyl-2,4-pentanediol, an analog of hexylene glycol, is a small molecular surfactant which could be useful as an environmentally friendly industrial coating solvent.
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CAS 107-41-5 2-Methyl-2,4-pentanediol

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Reference Reading

1.Avoiding Carbothermal Reduction: Distillation of Alkoxysilanes from Biogenic, Green, and Sustainable Sources.
Laine RM1,2, Furgal JC3, Doan P3, Pan D4, Popova V5, Zhang X6. Angew Chem Int Ed Engl. 2016 Jan;55(3):1065-9. doi: 10.1002/anie.201506838. Epub 2015 Dec 3.
The direct depolymerization of SiO2 to distillable alkoxysilanes has been explored repeatedly without success for 85 years as an alternative to carbothermal reduction (1900 °C) to Simet , followed by treatment with ROH. We report herein the base-catalyzed depolymerization of SiO2 with diols to form distillable spirocyclic alkoxysilanes and Si(OEt)4 . Thus, 2-methyl-2,4-pentanediol, 2,2,4-trimethyl-1,3-pentanediol, or ethylene glycol (EGH2 ) react with silica sources, such as rice hull ash, in the presence of NaOH (10 %) to form H2 O and distillable spirocyclic alkoxysilanes [bis(2-methyl-2,4-pentanediolato) silicate, bis(2,2,4-trimethyl-1,3-pentanediolato) silicate or Si(eg)2 polymer with 5-98 % conversion, as governed by surface area/crystallinity. Si(eg)2 or bis(2-methyl-2,4-pentanediolato) silicate reacted with EtOH and catalytic acid to give Si(OEt)4 in 60 % yield, thus providing inexpensive routes to high-purity precipitated or fumed silica and compounds with single Si-C bonds.
2.Crystallization and preliminary X-ray analysis of the periplasmic domain of FliP, an integral membrane component of the bacterial flagellar type III protein-export apparatus.
Fukumura T1, Furukawa Y1, Kawaguchi T2, Saijo-Hamano Y1, Namba K1, Imada K2, Minamino T1. Acta Crystallogr F Struct Biol Commun. 2014 Sep;70(Pt 9):1215-8. doi: 10.1107/S2053230X14014678. Epub 2014 Aug 27.
The bacterial flagellar proteins are transported via a specific export apparatus to the distal end of the growing structure for their self-assembly. FliP is an essential membrane component of the export apparatus. FliP has an N-terminal signal peptide and is predicted to have four transmembrane (TM) helices and a periplasmic domain (FliPP) between TM-2 and TM-3. In this study, FliPP from Thermotoga maritima (TmFliPP) and its selenomethionine derivative (SeMet-TmFliPP) were purified and crystallized. TmFliPP formed a homotetramer in solution. Crystals of TmFliPP and SeMet-TmFliPP were obtained by the hanging-drop vapour-diffusion technique with 2-methyl-2,4-pentanediol as a precipitant. These two crystals grew in the hexagonal space group P6222 or P6422, with unit-cell parameters a = b = 114.9, c = 193.8 Å. X-ray diffraction data were collected from crystals of TmFliPP and SeMet-TmFliPP to 2.4 and 2.8 Å resolution, respectively.
3.The role of 2-methyl-2, 4-pentanediol in sodium dodecyl sulfate micelle dissociation unveiled by dynamic light scattering and molecular dynamics simulations.
Roussel G1, Rouse SL2, Sansom MS3, Michaux C4, Perpète EA5. Colloids Surf B Biointerfaces. 2014 Feb 1;114:357-62. doi: 10.1016/j.colsurfb.2013.10.023. Epub 2013 Oct 30.
The development of efficient protein refolding techniques remains a challenge in biotechnology. In that context, it has recently been reported that the addition of 2-methyl-2, 4-pentanediol (MPD) to sodium dodecyl sulfate (SDS) allows the renaturation of both soluble and membrane proteins. The present work combines experimental (dynamic light scattering; DLS) and theoretical (molecular dynamics) approaches to study the molecular basis of the association between SDS and MPD, in order to understand its relevance in the refolding process. DLS shows the micelle dissociation in the presence of molar concentrations of MPD, and simulations reveal that this process results from a screening of the negative charge on the SDS headgroup and a minimization of the solvent (water) accessibility of the detergent tail. This suggests a mechanism whereby the combination of these effects leads to the shift from a "harsh" to a "gentle" detergent behavior, which in turn promotes a productive refolding of the protein.
4.Mometasone furoate-loaded cold processed oil-in-water emulsions: in vitro and in vivo studies.
Raposo S1, Tavares R, Gonçalves L, Simões S, Urbano M, Ribeiro HM. Drug Deliv. 2015;22(4):562-72. doi: 10.3109/10717544.2013.871086. Epub 2014 Feb 21.
Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are still on demand. The aim of this work was the in vitro and in vivo characterization of cold processed oil-in-water (o/w) emulsions intended for mometasone furoate (MF) delivery to induce drug targeting to upper skin strata, decreasing adverse effects. Two o/w emulsions, containing 0.1% of MF, were developed differing in the glycol used (2-methyl-2,4-pentanediol - PT and ethoxydiglycol - TC emulsions). In vitro permeation studies revealed that these emulsions are suitable vehicles for the delivery of MF containing ingredients which are responsible for a drastically increased on the permeability coefficients of MF from a theoretical value of 1.18 × 10(-4 )cm/h to 5.20 × 10(-4) ± 2.05 × 10(-4 )cm/h and 6.30 × 10(-4) ± 2.94 × 10(-4 )cm/h, for PT and TC, respectively.