2-Methyl-2,4-pentanediol - CAS 107-41-5
Not Intended for Therapeutic Use. For research use only.
Product Name:
Catalog Number:
CAS Number:
2-Methyl-2,4-pentanediol, an analog of hexylene glycol, is a small molecular surfactant which could be useful as an environmentally friendly industrial coating solvent.
Molecular Weight:
Molecular Formula:
Canonical SMILES:
Chemical Structure
CAS 107-41-5 2-Methyl-2,4-pentanediol

Related Products

(CAS: 460741-57-5)

A Metabolite of Pomalidomide.

(CAS: 102191-05-9)

ONO3708 is a potent antagonist of the thromboxane A2/prostaglandin endoperoxide receptor in vitro and in vivo. It could play an important role in the pathogenes...

CAS 28371-16-6 Aloin B

Aloin B
(CAS: 28371-16-6)

Aloin B is one isomer of Aloin; Aloin is a physiologically active anthraquinone present in aloe.

CAS 2920-86-7 Prednisolone hemisuccinate

Prednisolone hemisuccinate
(CAS: 2920-86-7)

Prednisolone hemisuccinate is a metabolite of a derivative of cortisol called Prednisolone. It can be used to treat a variety of inflammatory and auto-immune co...

CAS 29679-58-1 Fenoprofen

(CAS: 29679-58-1)

Fenoprofen is a non-steroidal anti-inflammatory drug, act as an anti-inflammatory analgesic and antipyretic highly bound to plasma proteins.

CAS 102841-42-9 Mulberroside A

Mulberroside A
(CAS: 102841-42-9)

Mulberroside A, extracted from the root bark of white mulberry, could reduce P-gp expression and function being along with the activation of PKC and NF-κB. It h...

(CAS: 180183-51-1)

CGP-62198A, a piperidine derivative, could probably be useful in some biological studies.

(CAS: 1353625-73-6)

Presatovir is a viral fusion protein inhibitor originated by Gilead Sciences with EC50 value of 0.43 nM. GS-5806 can inhibit a broad range of respiratory syncyt...

CAS 126-27-2 Oxethazaine

(CAS: 126-27-2)

Oxethazaine, an effective topical anesthetic, could be used to relieve the pain caused by peptic ulcer disease and esophagitis.

Epothilone F
(CAS: 208518-52-9)

Epothilone F, an active metabolite of Epothilone D, prevents cancer cells from dividing by interfering with tubulin.

KT 5926
(CAS: 126643-38-7)

KT 5926, an organic heterooctacyclic compound, selectively inhibits nerve growth factor-dependent neurite elongation.

(CAS: 1251537-11-7)

Navamepent is an inflammation mediator inhibitor and lipid modulator originated by Resolvyx Pharmaceuticals and licensed to Auven Therapeutics in 2011. Treatmen...

CAS 75-80-9 Tribromoethanol

(CAS: 75-80-9)

Tribromoethanol is a sedative. It is used to anesthetize laboratory animals, particularly rodents, prior to surgery. It has the brand name Avertin as a solution...

CAS 162784-72-7 7-Epi-10-oxo-docetaxel

(CAS: 162784-72-7)

Docetaxel Impurity

CAS 108437-28-1 Binfloxacin

(CAS: 108437-28-1)

Binfloxacin, a bio-active chemical compound, has antibiotic effect.

CAS 314728-85-3 Sunifiram

(CAS: 314728-85-3)

unifiram (DM-235) is a piperazine derived research chemical which has nootropic effects in animal studies with significantly higher potency than piracetam.

CAS 10206-21-0 Cefacetrile

(CAS: 10206-21-0)

Cefacetrile, a derivative of 7-aminocephalosporanic acid, is a broad-spectrum first generation cephalosporin with antibiotic and antibacterial activity. It is e...

CAS 10338-51-9 Salidroside

(CAS: 10338-51-9)

Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties.

CAS 70553-45-6 NS 3763

NS 3763
(CAS: 70553-45-6)

NS 3763 is a non-competitive kainate receptor antagonist of GLUK5 subunit-containing receptors (IC(50) = 1.6 microM)) without disrupting GLU(K6) subtype (IC(50)...

CAS 79-55-0 1,2,2,6,6-Pentamethylpiperidine

(CAS: 79-55-0)

1,2,2,6,6-Pentamethylpiperidine is a ganglion-blocking drug. It is one of the most strongly basic tertiary amine. It is ued as an oral treatment for hypertensio...

Reference Reading

1.Avoiding Carbothermal Reduction: Distillation of Alkoxysilanes from Biogenic, Green, and Sustainable Sources.
Laine RM1,2, Furgal JC3, Doan P3, Pan D4, Popova V5, Zhang X6. Angew Chem Int Ed Engl. 2016 Jan;55(3):1065-9. doi: 10.1002/anie.201506838. Epub 2015 Dec 3.
The direct depolymerization of SiO2 to distillable alkoxysilanes has been explored repeatedly without success for 85 years as an alternative to carbothermal reduction (1900 °C) to Simet , followed by treatment with ROH. We report herein the base-catalyzed depolymerization of SiO2 with diols to form distillable spirocyclic alkoxysilanes and Si(OEt)4 . Thus, 2-methyl-2,4-pentanediol, 2,2,4-trimethyl-1,3-pentanediol, or ethylene glycol (EGH2 ) react with silica sources, such as rice hull ash, in the presence of NaOH (10 %) to form H2 O and distillable spirocyclic alkoxysilanes [bis(2-methyl-2,4-pentanediolato) silicate, bis(2,2,4-trimethyl-1,3-pentanediolato) silicate or Si(eg)2 polymer with 5-98 % conversion, as governed by surface area/crystallinity. Si(eg)2 or bis(2-methyl-2,4-pentanediolato) silicate reacted with EtOH and catalytic acid to give Si(OEt)4 in 60 % yield, thus providing inexpensive routes to high-purity precipitated or fumed silica and compounds with single Si-C bonds.
2.Crystallization and preliminary X-ray analysis of the periplasmic domain of FliP, an integral membrane component of the bacterial flagellar type III protein-export apparatus.
Fukumura T1, Furukawa Y1, Kawaguchi T2, Saijo-Hamano Y1, Namba K1, Imada K2, Minamino T1. Acta Crystallogr F Struct Biol Commun. 2014 Sep;70(Pt 9):1215-8. doi: 10.1107/S2053230X14014678. Epub 2014 Aug 27.
The bacterial flagellar proteins are transported via a specific export apparatus to the distal end of the growing structure for their self-assembly. FliP is an essential membrane component of the export apparatus. FliP has an N-terminal signal peptide and is predicted to have four transmembrane (TM) helices and a periplasmic domain (FliPP) between TM-2 and TM-3. In this study, FliPP from Thermotoga maritima (TmFliPP) and its selenomethionine derivative (SeMet-TmFliPP) were purified and crystallized. TmFliPP formed a homotetramer in solution. Crystals of TmFliPP and SeMet-TmFliPP were obtained by the hanging-drop vapour-diffusion technique with 2-methyl-2,4-pentanediol as a precipitant. These two crystals grew in the hexagonal space group P6222 or P6422, with unit-cell parameters a = b = 114.9, c = 193.8 Å. X-ray diffraction data were collected from crystals of TmFliPP and SeMet-TmFliPP to 2.4 and 2.8 Å resolution, respectively.
3.The role of 2-methyl-2, 4-pentanediol in sodium dodecyl sulfate micelle dissociation unveiled by dynamic light scattering and molecular dynamics simulations.
Roussel G1, Rouse SL2, Sansom MS3, Michaux C4, Perpète EA5. Colloids Surf B Biointerfaces. 2014 Feb 1;114:357-62. doi: 10.1016/j.colsurfb.2013.10.023. Epub 2013 Oct 30.
The development of efficient protein refolding techniques remains a challenge in biotechnology. In that context, it has recently been reported that the addition of 2-methyl-2, 4-pentanediol (MPD) to sodium dodecyl sulfate (SDS) allows the renaturation of both soluble and membrane proteins. The present work combines experimental (dynamic light scattering; DLS) and theoretical (molecular dynamics) approaches to study the molecular basis of the association between SDS and MPD, in order to understand its relevance in the refolding process. DLS shows the micelle dissociation in the presence of molar concentrations of MPD, and simulations reveal that this process results from a screening of the negative charge on the SDS headgroup and a minimization of the solvent (water) accessibility of the detergent tail. This suggests a mechanism whereby the combination of these effects leads to the shift from a "harsh" to a "gentle" detergent behavior, which in turn promotes a productive refolding of the protein.
4.Mometasone furoate-loaded cold processed oil-in-water emulsions: in vitro and in vivo studies.
Raposo S1, Tavares R, Gonçalves L, Simões S, Urbano M, Ribeiro HM. Drug Deliv. 2015;22(4):562-72. doi: 10.3109/10717544.2013.871086. Epub 2014 Feb 21.
Over the years, research has focused on strategies to increase benefit/risk ratio of corticoids. However, vehicles intended for topical glucocorticoids delivery with an improved benefit/risk ratio are still on demand. The aim of this work was the in vitro and in vivo characterization of cold processed oil-in-water (o/w) emulsions intended for mometasone furoate (MF) delivery to induce drug targeting to upper skin strata, decreasing adverse effects. Two o/w emulsions, containing 0.1% of MF, were developed differing in the glycol used (2-methyl-2,4-pentanediol - PT and ethoxydiglycol - TC emulsions). In vitro permeation studies revealed that these emulsions are suitable vehicles for the delivery of MF containing ingredients which are responsible for a drastically increased on the permeability coefficients of MF from a theoretical value of 1.18 × 10(-4 )cm/h to 5.20 × 10(-4) ± 2.05 × 10(-4 )cm/h and 6.30 × 10(-4) ± 2.94 × 10(-4 )cm/h, for PT and TC, respectively.