2-MethoxyiminoFurylacetic acid amonium salt - CAS 97148-89-5

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2-MethoxyiminoFurylacetic acid amonium salt
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CAS 97148-89-5 2-MethoxyiminoFurylacetic acid amonium salt
Reference Reading
1.Synthesis and biological evaluation of N-naphthoyl-phenylglyoxamide-based small molecular antimicrobial peptide mimics as novel antimicrobial agents and biofilm inhibitors.
Nizalapur S1, Ho KK, Kimyon Ö, Yee E, Berry T, Manefield M, Cranfield CG, Willcox M, Black DS, Kumar N. Org Biomol Chem. 2016 Apr 14;14(14):3623-37. doi: 10.1039/c6ob00298f. Epub 2016 Mar 17.
Antimicrobial peptides (AMPs) are a key component of the human immune system. Synthetic AMP mimics represent a novel strategy to counteract the increasing incidence of antimicrobial resistance. Here, we describe the synthesis of novel glyoxamide derivatives via ring-opening reactions of N-hexanoyl, N-benzoyl and N-naphthoylisatins with N,N-dimethylethane-1,2-diamine and N,N-dimethylpropane-1,3-diamine. These were converted to both the hydrochloric acid (HCl) or quaternary ammonium iodide (MeI) salts and their antibacterial activity against Staphylococcus aureus was investigated by their zone-of-inhibition and minimum inhibitory concentration (MIC). The HCl salt 22b exhibited the lowest MIC of 16 μg mL(-1), whereas the corresponding MeI salt 22c had a MIC of 39 μg mL(-1). We also investigated the in vitro toxicity of active compounds against the MRC-5 normal human lung fibroblasts and their activity against established biofilm in S. aureus.
2.Silicon Nitride Bioceramics Induce Chemically Driven Lysis in Porphyromonas gingivalis.
Pezzotti G1,2, Bock RM3, McEntire BJ3, Jones E3, Boffelli M1,4, Zhu W5, Baggio G1,4, Boschetto F1,4, Puppulin L2, Adachi T4, Yamamoto T4, Kanamura N4, Marunaka Y2, Bal BS3,6. Langmuir. 2016 Mar 29;32(12):3024-35. doi: 10.1021/acs.langmuir.6b00393. Epub 2016 Mar 16.
Organisms of Gram-negative phylum bacteroidetes, Porphyromonas gingivalis, underwent lysis on polished surfaces of silicon nitride (Si3N4) bioceramics. The antibacterial activity of Si3N4 was mainly the result of chemically driven principles. The lytic activity, although not osmotic in nature, was related to the peculiar pH-dependent surface chemistry of Si3N4. A buffering effect via the formation of ammonium ions (NH4(+)) (and their modifications) was experimentally observed by pH microscopy. Lysis was confirmed by conventional fluorescence spectroscopy, and the bacteria's metabolism was traced with the aid of in situ Raman microprobe spectroscopy. This latter technique revealed the formation of peroxynitrite within the bacterium itself. Degradation of the bacteria's nucleic acid, drastic reduction in phenilalanine, and reduction of lipid concentration were observed due to short-term exposure (6 days) to Si3N4. Altering the surface chemistry of Si3N4 by either chemical etching or thermal oxidation influenced peroxynitrite formation and affected bacteria metabolism in different ways.
3.Novel Ion-Exchange Coagulants Remove More Low Molecular Weight Organics than Traditional Coagulants.
Zhao H1,2, Wang L1,2, Hanigan D3, Westerhoff P3, Ni J1,2. Environ Sci Technol. 2016 Apr 5;50(7):3897-904. doi: 10.1021/acs.est.6b00635. Epub 2016 Mar 22.
Low molecular weight (MW) charged organic matter is poorly removed by conventional coagulants but contributes to disinfection byproduct formation during chlorination of drinking waters. We hypothesized that CIEX, a new Al-based hybrid coagulant with ion-exchange functional groups, would be new mechanistic approach to remove low MW organic matter during coagulation and would perform better than polyaluminum chloride (PACl) or metal-salt based coagulants. We measured coagulation performance using dissolved organic carbon (DOC) in a high hardness surface water. CIEX achieved excellent turbidity removal and removed 20% to 46% more DOC than FeCl3, Al2(SO4)3, or PACl, depending on dose. The improved DOC removal was attributable to better removal of low MW organic matter (<2 kDa). We further studied removal mechanisms in a model water containing a low MW organic acid (salicylic acid (SA)). CIEX achieved high removal of organic acids (>90% of SA) independent of pH, whereas removal by metal salts was lower (<15%) and was strongly pH dependent.
4.Enrichment of the Glycyrrhizic Acid from Licorice Roots (Glycyrrhiza glabra L.) by Isoelectric Focused Adsorptive Bubble Chromatography.
Karaoğul E1, Parlar P2, Parlar H3, Alma MH1. J Anal Methods Chem. 2016;2016:7201740. doi: 10.1155/2016/7201740. Epub 2016 Feb 1.
The main aim of this study was to enrich glycyrrhizic acid ammonium salt known as one of the main compounds of licorice roots (Glycyrrhiza glabra L.) by isoelectric focused adsorptive bubble separation technique with different foaming agents. In the experiments, four bubble separation parameters were used with β-lactoglobulin, albumin bovine, and starch (soluble) preferred as foaming agents and without additives. The enrichment of glycyrrhizic acid ammonium salt into the foam was influenced by different additive substances. The results showed that highest enrichment values were obtained from β-lactoglobulin as much as 368.3 times. The lowest enrichment values (5.9 times) were determined for the application without additive. After enrichment, each experiment of glycyrrhizic acid ammonium salt confirmed that these substances could be quantitatively enriched into the collection vessel with isoelectric focused adsorptive bubble separation technique.
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