2-Hydroxybenzyl alcohol - CAS 90-01-7
Not Intended for Therapeutic Use. For research use only.
Product Name:
2-Hydroxybenzyl alcohol
Catalog Number:
2-Hydroxybenzenemethanol; o-Hydroxybenzyl Alcohol; 1-(o-Hydroxyphenyl)methanol; 2-Hydroxybenzenemethanol; 2-Hydroxybenzyl alcohol; 2-Hydroxymethylphenol; 2-Methylolphenol; Diathesin; NSC 3814; Salicain; Salicyl Alcohol; Salicylic Alcohol; Saligenin; Salig
CAS Number:
2-Hydroxybenzyl alcohol could be extracted from salix bark. And this is the reason for 2-Hydroxybenzyl alcohol being named "Salicyl alcohol". It is an precursor of salicylic acid and also have some extent of anti-depressant and anti-melanomic effect.
Molecular Weight:
Molecular Formula:
Canonical SMILES:
Chemical Structure
CAS 90-01-7 2-Hydroxybenzyl alcohol

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Reference Reading

1.Gastrodin production from p-2-hydroxybenzyl alcohol through biotransformation by cultured cells of Aspergillus foetidus and Penicillium cyclopium.
Fan L1, Dong Y, Xu T, Zhang H, Chen Q. Appl Biochem Biotechnol. 2013 May;170(1):138-48. doi: 10.1007/s12010-013-0166-6. Epub 2013 Mar 13.
The objective of this work was to take advantage of the resting cells of suitable fungus as an in vitro model to prepare gastrodin from p-2-hydroxybenzyl alcohol (HBA), which mainly exists in the metabolites of the plant Gastrodia elata Blume. The one-step biotransformation of HBA into gastrodin was examined with the filamentous fungi cells of Aspergillus foetidus and Penicillium cyclopium AS 3.4513 in this study. The fundamental conditions of biotransformation were screened and compared for both fungi. P. cyclopium AS 3.4513 had better gastrodin-producing capability than A. foetidus through one-step bioconversion. The highest yield of gastrodin was 36 mg/L for A. foetidus ZU-G1 and 65 mg/L for P. cyclopium AS 3.4513 under the respective development condition during 6 days of biotransformation. The comparative results show that P. cyclopium AS 3.4513 reveals great potential to form gastrodin using HBA as the precursor. The products catalyzed by the resting cells of P.
2.Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates.
Ali G1, Subhan F, Islam NU, Ullah N, Sewell RD, Shahid M, Khan I. Naunyn Schmiedebergs Arch Pharmacol. 2014 Mar;387(3):281-90. doi: 10.1007/s00210-013-0941-5. Epub 2013 Nov 29.
The present study was conducted to synthesize nitrogen containing derivatives of salicyl alcohol and to investigate in vivo their ulcerogenic potential in comparison with aspirin in rats. The compounds [4-(2-hydroxybenzyl) morpholin-4-iumchloride (I)] and [1,4-bis(2-hydroxybenzyl) piperazine-1,4-diium chloride (II)] were synthesized and their chemical structures were characterized using spectral data. In our previous study (Ali et al., Afr J Pharm Pharmacol 7:585-596, 2013), both compounds showed anti-inflammatory, antinociceptive, and antipyretic properties in standard animal models and a greater binding affinity for cyclooxygenase-2 versus cyclooxygenase-1 in molecular docking and dynamics analysis. For in vivo studies, animals were randomly divided into four groups. The synthetic compounds (both at 100 or 150 mg/kg), aspirin (150 mg/kg), or saline vehicle was administered orally, once daily for 6 days and then tested for ulcerogenic activity.
3.Liposomes by polymerization of an imidazolium ionic liquid: use as microreactors for gold-catalyzed alcohol oxidation.
Buaki M1, Aprile C, Dhakshinamoorthy A, Alvaro M, Garcia H. Chemistry. 2009 Dec 7;15(47):13082-9. doi: 10.1002/chem.200902395.
The bipodal ionic liquid N,N'-bis(10-undecenyl)-2-methylimidazolium underwent polymerization in aqueous media with potassium persulfate to form submicrometric liposomes. A TEM study indicated that the liposomes are the result of several morphological transformations of the polymer particles. Photopolymerization at room temperature led to spherical particles with some internal voids and polymer chains. We took advantage of the positive charge on the imidazolium rings and used a photocuring agent to form in a single step starting from the imidazolium monomer and NaAuCl(4) spherical polymer particles containing gold nanoparticles (10-15 nm) in their interior. This system was found to promote the selective aerobic oxidation of 2-hydroxybenzyl alcohol to salicylaldehyde.
4.Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study.
Ali G1, Subhan F, Islam NU, Ullah N, Shahid M, Ullah S, Ullah I, Shah R, Khan I, Sewell RD, Abbas G. Arch Pharm Res. 2014 Jul;37(7):916-26. doi: 10.1007/s12272-013-0245-9. Epub 2013 Oct 2.
The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes.