2-Ethoxybenzamide - CAS 938-73-8
Not Intended for Therapeutic Use. For research use only.
Product Name:
Catalog Number:
2-Ethoxybenzenecarbonamide;Anovigam;Benzamide, 2-ethoxy-;Benzamide, O-ethoxy-;Etamide;Etenzamide;Ethbenzamide;O-Ethoxybenzamide
CAS Number:
2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug. It is used to reduce the fever, headaches, and other minor aches and pains. It is an ingredient in numerous cold medications and many prescription analgesics. It has been listed.
Molecular Weight:
Molecular Formula:
Kilogram to ton
Quality Standard:
JP standard
Canonical SMILES:
Current Developer:
2-Ethoxybenzamide has been listed.
Chemical Structure
CAS 938-73-8 2-Ethoxybenzamide

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Reference Reading

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Iwao Y1, Tanaka S, Uchimoto T, Noguchi S, Itai S. Int J Pharm. 2013 May 1;448(1):1-8. doi: 10.1016/j.ijpharm.2013.03.012. Epub 2013 Mar 19.
With the aim of directly predicting the functionality and mechanism of disintegrants during the disintegration and dissolution of tablets, we investigated an analysis method based on available surface area, which is the surface area of a drug in a formulation in direct contact with the external solvent during dissolution. We evaluated the following disintegrants in this study: sodium starch glycolate (Glycolys), crospovidone (Kollidon CL), carboxymethylcellulose calcium (CMC-Ca), low-substituted hydroxypropylcellulose (L-HPC), and croscarmellose sodium (Ac-Di-Sol). When disintegrant was added to a 50% ethenzamide tablet formulation, an increase in the dissolution rate dependent on disintegrant concentration was observed, according to the type of disintegrant. In addition, the available surface area also differed between disintegrants. For Glycolys, CMC-Ca, and Ac-Di-Sol, a rapid increase in available surface area and a large increase in maximum available surface area (Smax) were observed due to high swellability and wicking, even when the disintegrant concentration was only 1.
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The cocrystallization of salicylamide (2-hydroxybenzamide, SMD) and ethenzamide (2-ethoxybenzamide, EMD) with aromatic carboxylic acids was examined both experimentally and theoretically. The supramolecular synthesis taking advantage of the droplet evaporative crystallization (DEC) technique was combined with powder diffraction and vibrational spectroscopy as the analytical tools. This led to identification of eleven new cocrystals including pharmaceutically relevant coformers such as mono- and dihydroxybenzoic acids. The cocrystallization abilities of SMD and EMD with aromatic carboxylic acids were found to be unexpectedly divers despite high formal similarities of these two benzamides and ability of the R2,2(8) heterosynthon formation. The source of diversities of the cocrystallization landscapes is the difference in the stabilization of possible conformers by adopting alternative intramolecular hydrogen boding patterns. The stronger intramolecular hydrogen bonding the weaker affinity toward intermolecular complexation potential.
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With the aim of directly predicting the functionality and mechanism of pharmaceutical excipients, we investigated an analysis method based on available surface area (S(t)), which is the surface area of a drug in direct contact with the external solvent during dissolution. First, to study the effect of lubricant concentration on the dissolution rate of acetaminophen (APAP), the dissolution behaviors as well as the change over time in S(t) of APAP tablets were examined. In the dissolution tests, a retarded dissolution of APAP was not observed with new lubricant triglycerin full behenate (TR-FB), whereas magnesium stearate (Mg-St) retarded the dissolution. The S(t) profiles for APAP with Mg-St at>0.5% showed downward curvature indicating a gradual decrease in surface area over time. Conversely, with TR-FB, even when its concentration was increased, the S(t) profile for APAP had a maximum value. The differences between Mg-St and TR-FB could be explained by the differences in extensibility deriving from their morphology.
4.Integrating epigenetic modulators into NanoScript for enhanced chondrogenesis of stem cells.
Patel S1,2, Pongkulapa T1,2, Yin PT1,2, Pandian GN1,2, Rathnam C1,2, Bando T1,2, Vaijayanthi T1,2, Sugiyama H1,2, Lee KB1,2. J Am Chem Soc. 2015 Apr 15;137(14):4598-601. doi: 10.1021/ja511298n. Epub 2015 Apr 2.
N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide (CTB) is a small molecule that functions by altering the chromatin architecture to modulate gene expression. We report a new CTB derivative with increased solubility and demonstrate CTB's functionality by conjugating it on the recently established NanoScript platform to enhance gene expression and induce stem cell differentiation. NanoScript is a nanoparticle-based artificial transcription factor that emulates the structure and function of transcription factor proteins (TFs) to effectively regulate endogenous gene expression. Modifying NanoScript with CTB will more closely replicate the TF structure and enhance CTB functionality and gene expression. To this end, we first conjugated CTB onto NanoScript and initiated a time-dependent increase in histone acetyltransferase activity. Next, because CTB is known to trigger the pathway involved in regulating Sox9, a master regulator of chondrogenic differentiation, we modifed a Sox9-specific NanoScript with CTB to enhance chondrogenic gene activity and differentiation.