2-Ethoxybenzamide - CAS 938-73-8
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
2-Ethoxybenzamide
Catalog Number:
938-73-8
Synonyms:
2-Ethoxybenzenecarbonamide;Anovigam;Benzamide, 2-ethoxy-;Benzamide, O-ethoxy-;Etamide;Etenzamide;Ethbenzamide;O-Ethoxybenzamide
CAS Number:
938-73-8
Description:
2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug. It is used to reduce the fever, headaches, and other minor aches and pains. It is an ingredient in numerous cold medications and many prescription analgesics. It has been listed.
Molecular Weight:
165.19
Molecular Formula:
C9H11NO2
Quantity:
Kilogram to ton
Quality Standard:
JP standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CCOC1=CC=CC=C1C(=O)N
InChI:
InChI=1S/C9H11NO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H2,10,11)
InChIKey:
SBNKFTQSBPKMBZ-UHFFFAOYSA-N
Targets:
Others
Current Developer:
2-Ethoxybenzamide has been listed.
Chemical Structure
CAS 938-73-8 2-Ethoxybenzamide

Related Products


CAS 56-04-2 Methylthiouracil

Methylthiouracil
(CAS: 56-04-2)

Methylthiouracil is an antithyroid preparation.The drug acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland.

Amitifadine
(CAS: 410074-73-6)

Amitifadine is an antidepressant drug candidate which reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (ME...

CAS 89250-26-0 Astragalus polysaccharide

Astragalus polysaccharide
(CAS: 89250-26-0)

Astragalus polysaccharide is one kind of biological macromolecule extracted from Astragalus. It has antiviral activities.

GSK-2262167 sodium
(CAS: 1165923-54-5)

This molecular is a potent S1P3-sparing and S1P1 agonist. Meanwhile GSK-2262167 has a potent activity is in a collagen-induced arthritis model as efficacious as...

CAS 106308-44-5 Rufinamide

Rufinamide
(CAS: 106308-44-5)

Rufinamide (E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive ther...

CAS 1597-82-6 Paramethasone acetate

Paramethasone acetate
(CAS: 1597-82-6)

Paramethasone Acetate, a derivative of dexamethasone, has been found to be a glucocorticoid drug and could be used in some inflammatory diseases.

CAS 22232-54-8 Carbimazole

Carbimazole
(CAS: 22232-54-8)

Carbimazole is used to treat hyperthyroidism. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevent...

CAS 213400-34-1 UPF-648

UPF-648
(CAS: 213400-34-1)

Potent and selective inhibitor of kynurenine-3-monooxygenase (KMO, or kynurenine hydroxylase) activity (IC50: 20 nM); Active (+)-(1S,2S)-enantiomer; Useful tool...

ACT-246475
(CAS: 1159500-34-1)

This active molecular is a reversible and selective platelet P2Y12 receptor antagonist. IC50 value of ACT-246475 is 8.0 nM. ACT-246475 dose-dependently blocked ...

CAS 1665-48-1 Metaxalone

Metaxalone
(CAS: 1665-48-1)

Metaxalone is a muscle relaxant. The mechanism of action of metaxalone in humans is not fully understood. It was suggested that it acts through general central ...

CAS 5949-44-0 Testosterone undecanoate

Testosterone undecanoate
(CAS: 5949-44-0)

A metabolite of Testosterone, which is a promising androgen for male hormonal contraception.

CAS 370-86-5 FCCP

FCCP
(CAS: 370-86-5)

As A very potent uncoupler of oxidative phosphorylation in mitochondria, FCCP transports protons across cell membranes which disrupts ATP synthesis,

CFLZ-567
(CAS: 868540-16-3)

CFLZ-567 is a key intermediate for making carfilzomib. carfilzomib is a selective proteasome inhibitor as an anti-cancer drug.

CAS 491-54-3 Kaempferide

Kaempferide
(CAS: 491-54-3)

Kaempferide is an O-methylated flavonol. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L...

AMZ30
(CAS: 1313613-09-0)

AMZ30, a PME-1 inhibitor, could inhibit PME-1 irreversiblely and be significant in the pharmacological study of determinating the demethylated PP2A function. IC...

Ridinilazole
(CAS: 308362-25-6)

Ridinilazole is a non-absorbable small molecule antibiotic for oral administration to treat Clostridium difficile infection (CDI), showed statistical superiorit...

CK 683A
(CAS: 83539-21-3)

CK 683A is a bio-active chemical,but no detailed information has been published yet.

FCE 26644
(CAS: 154788-16-6)

FCE 26644, also known as PNU-145156E, has been found to be a angiogenesis inhibitor that could have probable effect against solid tumours. It has already been d...

CAS 101917-30-0 Sodium 4-pentynoate

Sodium 4-pentynoate
(CAS: 101917-30-0)

Sodium 4-pentynoate, an alkynylacetate analogue, can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acet...

FR 75513
(CAS: 127975-78-4)

FR 75513 is a 1,1'-biphenyl-2,6-dicarboxylic acid diester compound with inhibitory activity on guinea-pig detrusor muscle contraction at electrical field stimul...

Reference Reading


1.An easy-to-use approach for determining the disintegration ability of disintegrants by analysis of available surface area.
Iwao Y1, Tanaka S, Uchimoto T, Noguchi S, Itai S. Int J Pharm. 2013 May 1;448(1):1-8. doi: 10.1016/j.ijpharm.2013.03.012. Epub 2013 Mar 19.
With the aim of directly predicting the functionality and mechanism of disintegrants during the disintegration and dissolution of tablets, we investigated an analysis method based on available surface area, which is the surface area of a drug in a formulation in direct contact with the external solvent during dissolution. We evaluated the following disintegrants in this study: sodium starch glycolate (Glycolys), crospovidone (Kollidon CL), carboxymethylcellulose calcium (CMC-Ca), low-substituted hydroxypropylcellulose (L-HPC), and croscarmellose sodium (Ac-Di-Sol). When disintegrant was added to a 50% ethenzamide tablet formulation, an increase in the dissolution rate dependent on disintegrant concentration was observed, according to the type of disintegrant. In addition, the available surface area also differed between disintegrants. For Glycolys, CMC-Ca, and Ac-Di-Sol, a rapid increase in available surface area and a large increase in maximum available surface area (Smax) were observed due to high swellability and wicking, even when the disintegrant concentration was only 1.
2.Propensity of salicylamide and ethenzamide cocrystallization with aromatic carboxylic acids.
Przybyłek M1, Ziółkowska D2, Mroczyńska K3, Cysewski P4. Eur J Pharm Sci. 2016 Mar 31;85:132-40. doi: 10.1016/j.ejps.2016.02.010. Epub 2016 Feb 17.
The cocrystallization of salicylamide (2-hydroxybenzamide, SMD) and ethenzamide (2-ethoxybenzamide, EMD) with aromatic carboxylic acids was examined both experimentally and theoretically. The supramolecular synthesis taking advantage of the droplet evaporative crystallization (DEC) technique was combined with powder diffraction and vibrational spectroscopy as the analytical tools. This led to identification of eleven new cocrystals including pharmaceutically relevant coformers such as mono- and dihydroxybenzoic acids. The cocrystallization abilities of SMD and EMD with aromatic carboxylic acids were found to be unexpectedly divers despite high formal similarities of these two benzamides and ability of the R2,2(8) heterosynthon formation. The source of diversities of the cocrystallization landscapes is the difference in the stabilization of possible conformers by adopting alternative intramolecular hydrogen boding patterns. The stronger intramolecular hydrogen bonding the weaker affinity toward intermolecular complexation potential.
3.[Efficient Pharmaceutical Formulation Designs and Their Development Using Mathematical and Statistical Analysis].
Iwao Y1. Yakugaku Zasshi. 2015;135(10):1129-34. doi: 10.1248/yakushi.15-00195.
With the aim of directly predicting the functionality and mechanism of pharmaceutical excipients, we investigated an analysis method based on available surface area (S(t)), which is the surface area of a drug in direct contact with the external solvent during dissolution. First, to study the effect of lubricant concentration on the dissolution rate of acetaminophen (APAP), the dissolution behaviors as well as the change over time in S(t) of APAP tablets were examined. In the dissolution tests, a retarded dissolution of APAP was not observed with new lubricant triglycerin full behenate (TR-FB), whereas magnesium stearate (Mg-St) retarded the dissolution. The S(t) profiles for APAP with Mg-St at>0.5% showed downward curvature indicating a gradual decrease in surface area over time. Conversely, with TR-FB, even when its concentration was increased, the S(t) profile for APAP had a maximum value. The differences between Mg-St and TR-FB could be explained by the differences in extensibility deriving from their morphology.
4.Integrating epigenetic modulators into NanoScript for enhanced chondrogenesis of stem cells.
Patel S1,2, Pongkulapa T1,2, Yin PT1,2, Pandian GN1,2, Rathnam C1,2, Bando T1,2, Vaijayanthi T1,2, Sugiyama H1,2, Lee KB1,2. J Am Chem Soc. 2015 Apr 15;137(14):4598-601. doi: 10.1021/ja511298n. Epub 2015 Apr 2.
N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide (CTB) is a small molecule that functions by altering the chromatin architecture to modulate gene expression. We report a new CTB derivative with increased solubility and demonstrate CTB's functionality by conjugating it on the recently established NanoScript platform to enhance gene expression and induce stem cell differentiation. NanoScript is a nanoparticle-based artificial transcription factor that emulates the structure and function of transcription factor proteins (TFs) to effectively regulate endogenous gene expression. Modifying NanoScript with CTB will more closely replicate the TF structure and enhance CTB functionality and gene expression. To this end, we first conjugated CTB onto NanoScript and initiated a time-dependent increase in histone acetyltransferase activity. Next, because CTB is known to trigger the pathway involved in regulating Sox9, a master regulator of chondrogenic differentiation, we modifed a Sox9-specific NanoScript with CTB to enhance chondrogenic gene activity and differentiation.