2-Ethoxybenzamide - CAS 938-73-8
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
2-Ethoxybenzamide
Catalog Number:
938-73-8
Synonyms:
2-Ethoxybenzenecarbonamide;Anovigam;Benzamide, 2-ethoxy-;Benzamide, O-ethoxy-;Etamide;Etenzamide;Ethbenzamide;O-Ethoxybenzamide
CAS Number:
938-73-8
Description:
2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug. It is used to reduce the fever, headaches, and other minor aches and pains. It is an ingredient in numerous cold medications and many prescription analgesics. It has been listed.
Molecular Weight:
165.19
Molecular Formula:
C9H11NO2
Quantity:
Kilogram to ton
Quality Standard:
JP standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CCOC1=CC=CC=C1C(=O)N
InChI:
InChI=1S/C9H11NO2/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H2,10,11)
InChIKey:
SBNKFTQSBPKMBZ-UHFFFAOYSA-N
Targets:
Others
Current Developer:
2-Ethoxybenzamide has been listed.
Chemical Structure
CAS 938-73-8 2-Ethoxybenzamide

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Reference Reading


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With the aim of directly predicting the functionality and mechanism of pharmaceutical excipients, we investigated an analysis method based on available surface area (S(t)), which is the surface area of a drug in direct contact with the external solvent during dissolution. First, to study the effect of lubricant concentration on the dissolution rate of acetaminophen (APAP), the dissolution behaviors as well as the change over time in S(t) of APAP tablets were examined. In the dissolution tests, a retarded dissolution of APAP was not observed with new lubricant triglycerin full behenate (TR-FB), whereas magnesium stearate (Mg-St) retarded the dissolution. The S(t) profiles for APAP with Mg-St at>0.5% showed downward curvature indicating a gradual decrease in surface area over time. Conversely, with TR-FB, even when its concentration was increased, the S(t) profile for APAP had a maximum value. The differences between Mg-St and TR-FB could be explained by the differences in extensibility deriving from their morphology.
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N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide (CTB) is a small molecule that functions by altering the chromatin architecture to modulate gene expression. We report a new CTB derivative with increased solubility and demonstrate CTB's functionality by conjugating it on the recently established NanoScript platform to enhance gene expression and induce stem cell differentiation. NanoScript is a nanoparticle-based artificial transcription factor that emulates the structure and function of transcription factor proteins (TFs) to effectively regulate endogenous gene expression. Modifying NanoScript with CTB will more closely replicate the TF structure and enhance CTB functionality and gene expression. To this end, we first conjugated CTB onto NanoScript and initiated a time-dependent increase in histone acetyltransferase activity. Next, because CTB is known to trigger the pathway involved in regulating Sox9, a master regulator of chondrogenic differentiation, we modifed a Sox9-specific NanoScript with CTB to enhance chondrogenic gene activity and differentiation.