2-Chloromethyl-3,5-dimethyl-4-trifluoroethyl pyridine - CAS 256642-27-0
Catalog number: 256642-27-0
Category: Main Product
Molecular Formula:
C10H11ClF3N
Molecular Weight:
237.6492496
COA:
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Purity:
95%
Synonyms:
2-Chloromethyl-3,5-dimethyl-4-trifluoroethyl pyridine
MSDS:
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InChIKey:
PNWIIMKCJYBTAU-UHFFFAOYSA-N
InChI:
InChI=1S/C10H11ClF3N/c1-6-5-15-9(4-11)7(2)8(6)3-10(12,13)14/h5H,3-4H2,1-2H3
Canonical SMILES:
CC1=CN=C(C(=C1CC(F)(F)F)C)CCl
1.Method development and validation study for quantitative determination of 2-chloromethyl-3,4-dimethoxy pyridine hydrochloride a genotoxic impurity in pantoprazole active pharmaceutical ingredient (API) by LC/MS/MS.
Venugopal N1, Bhaskar Reddy AV, Gangadhar Reddy K, Madhavi V, Madhavi G. J Pharm Biomed Anal. 2012 Nov;70:592-7. doi: 10.1016/j.jpba.2012.05.031. Epub 2012 Jun 5.
A sensitive and selective liquid chromatographic-tandem mass spectrometric (LC/MS/MS) method was developed and validated for the trace analysis (>1 ppm level) of 2-chloromethyl-3,4-dimethoxy pyridine hydrochloride a genotoxic impurity in pantoprazole sodium drug substances. LC/MS/MS analysis of 2-chloromethyl-3,4-dimethoxy pyridine hydrochloride was done on Hypersil BDS C18 (50 mm × 4.6 mm) 3 μm column and 10 mM ammonium acetate in 1000 mL of water was used as buffer. The mobile phase used was in the ratio of buffer-acetonitrile (79:21, v/v). The flow rate was 1.0 mL/min and elution was monitored at 210 nm. The method was validated as per International Conference on Harmonization (ICH) guidelines. LC/MS/MS is able to quantitate up to 0.3 ppm of 2-chloromethyl-3,4-dimethoxy pyridine hydrochloride.
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CAS 256642-27-0 2-Chloromethyl-3,5-dimethyl-4-trifluoroethyl pyridine

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