1.Thiol-ene click chemistry derived cationic cyclodextrin chiral stationary phase and its enhanced separation performance in liquid chromatography.
Yao X1, Tan TT2, Wang Y3. J Chromatogr A. 2014 Jan 24;1326:80-8. doi: 10.1016/j.chroma.2013.12.054. Epub 2013 Dec 24.
This work is the first demonstration of a simple thiol-ene click chemistry to anchor vinyl imidazolium β-CD onto thiol silica to form a novel cationic native cyclodextrin (CD) chiral stationary phase (CSP). The CSP afforded high enantioseparation ability towards dansyl (Dns) amino acids, carboxylic aryl compounds and flavonoids in chiral HPLC. The current CSP demonstrates the highest resolving ability (selectivity >1.1, resolution >1.5) towards Dns amino acids in a mobile phase buffered at pH=6.5, with the resolution of Dns-dl-leucine as high as 6.97. 2,4-dichloride propionic acid (2,4-ClPOPA) was well resolved with the selectivity and resolution of 1.37 and 4.88, respectively. Compared to a previously reported native CD-CSP based on a triazole linkage, the current cationic CD-CSP shows a stronger retention and higher resolution towards acidic chiral compounds, ascribed to the propitious strong electrostatic attraction. Stability evaluation results indicated that thiol-ene reaction can provide a facile and robust approach for the preparation of positively charged CD CSPs.
2.Heterogeneous reactivity of suspended pirimiphos-methyl particles with ozone.
Yang B1, Zhang Y, Meng J, Gan J, Shu J. Environ Sci Technol. 2010 May 1;44(9):3311-6. doi: 10.1021/es9029599.
Pirimiphos-methyl (PMM) is a widely used pesticide that can be released into the atmosphere in the gas phase and the condensed phase. The reaction of suspended PMM particles with ozone is investigated using an online vacuum ultraviolet photoionization aerosol time-of-flight mass spectrometer (VUV-ATOFMS) and a scanning mobility particle sizer (SMPS). The reactions are conducted in an 180 L reaction chamber. The identification of particulate products detected with VUV-ATOFMS is proposed on the basis of GC-MS analysis of PMM ozonation products in methylene dichloride solution. The heterogeneous reactive rate constant of PMM with azelaic acid as matrix under room temperature (293 +/- 2 K) is (1.97 +/- 0.25) x 10(-17) cm(3) molecules(-1) s(-1). The corresponding lifetime at 100 ppbv of ozone is 5.2 +/- 0.66 h, and the reactive uptake coefficient (gamma) for ozone on PMM particles is (8.5 +/- 1.1) x 10(-4). Additionally, ozonation of PMM vapor is conducted, and the rapid formation of secondary organic aerosol (SOA) is observed in the homogeneous ozonation of gas-phase PMM.
3.Comparison of muscle paralysis after intravenous and intraosseous administration of succinylcholine in Swine.
Loughren MJ, Kilbourn J, Worth K, Burgert J, Gegel B, Johnson D. J Spec Oper Med. 2014 Summer;14(2):35-7.
AIM: To compare the onset and duration of intravenous (IV) and intraosseous (IO) administration of succinylcholine in swine.
4.Desaturation following rapid sequence induction using succinylcholine vs. rocuronium in overweight patients.
Tang L1, Li S, Huang S, Ma H, Wang Z. Acta Anaesthesiol Scand. 2011 Feb;55(2):203-8. doi: 10.1111/j.1399-6576.2010.02365.x.
BACKGROUND: Rapid sequence induction may be associated with hypoxemia. The purpose of this study was to investigate the possible difference in desaturation during rapid sequence induction in overweight patients using either succinylcholine or rocuronium.