2,5-DIHYDROXYPYRIDINE - CAS 24154-26-5

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Category
Main Product
Product Name
2,5-DIHYDROXYPYRIDINE
Catalog Number
24154-26-5
Synonyms
2,5-PYRIDINEDIOL; 2,5-DIHYDROXYPYRIDINE; 5-HYDROXY-2-PYRIDONE; 5-Hydroxypyridine-2(1H)-one
CAS Number
24154-26-5
Molecular Weight
111.1
Molecular Formula
C5H5NO2
COA
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MSDS
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Canonical SMILES
C1=CC(=O)NC=C1O
InChI
InChI=1S/C5H5NO2/c7-4-1-2-5(8)6-3-4/h1-3,7H,(H,6,8)
InChIKey
CHGPEDOMXOLANF-UHFFFAOYSA-N
Structure
CAS 24154-26-5 2,5-DIHYDROXYPYRIDINE
Specification
Purity
95%
Reference Reading
1.A preliminary crystallographic study of recombinant NicX, an Fe(2+)-dependent 2,5-dihydroxypyridine dioxygenase from Pseudomonas putida KT2440.
Jiménez JI1, Acebrón I, García JL, Díaz E, Mancheño JM. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt 5):549-53. doi: 10.1107/S174430911001119X. Epub 2010 Apr 29.
NicX from Pseudomonas putida KT2440 is an Fe(2+)-dependent dioxygenase that is involved in the aerobic degradation of nicotinic acid. The enzyme converts 2,5-dihydroxypyridine to N-formylmaleamic acid when overexpressed in Escherichia coli. Biophysical characterization of NicX by analytical gel-filtration chromatography revealed that it behaves as an oligomeric assembly in solution, with an apparent molecular weight that is consistent with a hexameric species. NicX was crystallized by the hanging-drop vapour-diffusion method at 291 K. Diffraction data were collected to a resolution of 2.0 A at the ESRF. The crystals most probably belong to the orthorhombic space group C222 or C222(1). The estimated Matthews coefficient was 2.4 A(3) Da(-1), corresponding to 50% solvent content, which is consistent with the presence of three protein molecules in the asymmetric unit. Analysis of the crystal data together with chromatographic results supports NicX being a hexameric assembly composed of two cyclic trimers.
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