1.Synthesis, characterization and cytotoxicity of a carboxylic ligand 2,2-bis(3-phenylpropyl) malonic acid and a corresponding Mn(II) complex.
Zhu MC1, Dai L, Gao EJ, Lin L, Wang B, Liu L. Dalton Trans. 2012 Nov 21;41(43):13352-8. doi: 10.1039/c2dt31635h.
The organic ligand Hbpmc and the polymeric complex [Mn(bpmc)(2)(4,4'-bipy)(H(2)O)(2)](n)·3H(2)O (4,4'-bipy = 4,4'-bipyridine, Hbpmc = 2,2-bis(3-phenylpropyl) malonic acid), which have both a lipophilic group (aromatic ring) and a hydrophilic group (non-coordination carboxyl), were synthesized and characterized by IR spectra, elemental analysis and X-ray single-crystal diffraction. The interaction of the complexes with HC-DNA was investigated by fluorescence spectroscopy. Gel electrophoresis assay demonstrates the ability to cleave the extracted HC-DNA. The value of IC(50) is to understand the effect of cytotoxic activity which is lower than cisplatin and higher than the ligand Hbpmc. The apoptotic tests show that the complexes apparently have an apoptotic effect on Hela cells.
2.A Co(II) thiocyanato coordination polymer with 4-(3-phenylpropyl)pyridine: the influence of the co-ligand on the magnetic properties.
Werner J1, Rams M, Tomkowicz Z, Näther C. Dalton Trans. 2014 Dec 14;43(46):17333-42. doi: 10.1039/c4dt02271h.
Three new coordination compounds with the composition Co(NCS)2(4-(3-phenylpropyl)pyridine)4 (1), Co(NCS)2(4-(3-phenylpropyl)pyridine)4(H2O)2 (2) and [Co(NCS)2(4-(3-phenylpropyl)pyridine)2]n (3) were prepared and investigated. The crystal structures of compounds 1 and 2 consist of discrete complexes, in which the Co(II) cations are coordinated by only terminal N-bonded thiocyanato anions. In the crystal structure 3 of the Co(II) cations are linked into chains by pairs of μ-1,3-bridging thiocyanato anions. DTA-TG measurements on compound 1 show decomposition without the formation of 3 as an intermediate. In contrast, on heating compound 2 two water molecules are removed in the first step leading to the formation of compound 3 in the second step. Magnetic measurements on reveal ferromagnetic interactions between Co(II) ions along chains with J = 29.5(1) K, and also ferromagnetic interactions between chains with zJ' = 0.38(1) K. The ferromagnetic transition is observed at 3.