2-(3-HYDROXYPROP-1-YNYL)BENZONITRILE - CAS 210884-99-4
Category:
Main Product
Product Name:
2-(3-HYDROXYPROP-1-YNYL)BENZONITRILE
Catalog Number:
210884-99-4
Synonyms:
2-(3-hydroxyprop-1-ynyl)benzonitrile; 210884-99-4; 2-(3-hydroxyprop-1-yn-1-yl)benzonitrile; ZINC02525642; AC1N4E1J; Ambcb4030363
CAS Number:
210884-99-4
Molecular Weight:
157.17
Molecular Formula:
C10H7NO
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
C1=CC=C(C(=C1)C#CCO)C#N
InChI:
InChI=1S/C10H7NO/c11-8-10-5-2-1-4-9(10)6-3-7-12/h1-2,4-5,12H,7H2
InChIKey:
ABSXJTJGIGJBOE-UHFFFAOYSA-N
Chemical Structure
CAS 210884-99-4 2-(3-HYDROXYPROP-1-YNYL)BENZONITRILE

Reference Reading


1.Synthesis of naphthalene amino esters and arylnaphthalene lactone lignans through tandem reactions of 2-alkynylbenzonitriles.
He Y1, Zhang X, Fan X. Chem Commun (Camb). 2014 May 30;50(42):5641-3. doi: 10.1039/c4cc01738b.
Tandem reaction of 2-alkynylbenzonitriles with a Reformatsky reagent turned out to be a novel and efficient approach toward 1-aminonaphthalene-2-carboxylates. Interestingly, with 2-(3-hydroxyprop-1-ynyl)benzonitriles as the substrates, a more sophisticated cascade process occurred to give 9-aminonaphtho[2,3-c]furan-1(3H)-ones in good yields. By using this tandem reaction as a key step, a concise and versatile synthetic strategy for the total synthesis of arylnaphthalene lactone lignans has been developed.