2,3,4,6-Tetra-O-pivaloyl-b-D-galactopyranosyl isothiocyanate - CAS 147948-52-5
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2,3,4,6-Tetra-O-pivaloyl-b-D-galactopyranosyl isothiocyanate
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CAS 147948-52-5 2,3,4,6-Tetra-O-pivaloyl-b-D-galactopyranosyl isothiocyanate

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1.Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation.
Choi HS1, Kim MK1, Choi YK2,3, Shin YC3, Cho SG4, Ko SG5. BMC Complement Altern Med. 2016 Apr 27;16(1):122. doi: 10.1186/s12906-016-1103-3.
BACKGROUND: Rhus verniciflua Stokes (RVS) belongs to the Anacardiaceae family and traditionally used for cancer treatment. RVS and butein, a major compound of RVS, were known to induce apoptosis via AKT inhibition in cancer cells. Thus, in this study, we investigated the effect of RVS and its derivative compounds (fisetin, quercetin, butein) on cell death in SKOV-3/PAX cells.
2.Anticancer Effects of 1,3-Dihydroxy-2-Methylanthraquinone and the Ethyl Acetate Fraction of Hedyotis Diffusa Willd against HepG2 Carcinoma Cells Mediated via Apoptosis.
Li YL1, Zhang J1, Min D1, Hongyan Z1, Lin N1, Li QS1. PLoS One. 2016 Apr 11;11(4):e0151502. doi: 10.1371/journal.pone.0151502. eCollection 2016.
Hedyotis Diffusa Willd, used in Traditional Chinese Medicine, is a treatment for various diseases including cancer, owing to its mild effectiveness and low toxicity. The aim of this study was to identify the main anticancer components in Hedyotis Diffusa Willd, and explore mechanisms underlying their activity. Hedyotis Diffusa Willd was extracted and fractionated using ethyl acetate to obtain the H-Ethyl acetate fraction, which showed higher anticancer activity than the other fractions obtained against HepG2 cells with sulforhodamine B assays. The active component of the H-Ethyl acetate fraction was identified to be 1,3-dihydroxy-2-methylanthraquinone (DMQ) with much high inhibitory rate up to 48.9 ± 3.3% and selectivity rate up to 9.4 ± 4.5 folds (p<0.01) at 125 μmol/L. HepG2 cells treated with the fraction and DMQ visualized morphologically using light and fluorescence microscopy. Annexin V-fluorescein isothiocyanate / propidium iodide staining flow cytometry, DNA ladder and cell cycle distribution assays.
3.Phenethyl isothiocyanate and indole-3-carbinol from cruciferous vegetables, but not furanocoumarins from apiaceous vegetables, reduced PhIP-induced DNA adducts in Wistar rats.
Kim JK1, Gallaher DD2, Chen C2, Gallaher CM2, Yao D2, Trudo SP1. Mol Nutr Food Res. 2016 May 2. doi: 10.1002/mnfr.201500790. [Epub ahead of print]
SCOPE: We previously showed that apiaceous but not cruciferous vegetables reduced DNA adducts formed by 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) in rats. Here, we report the effects of the putative chemopreventive phytochemicals from these vegetables on PhIP metabolism and DNA adduct formation.
4.Insertion of phenyl isothiocyanate into a P-P bond of a nickel-substituted bicyclo[1.1.0]tetraphosphabutane.
Pelties S1, Ehlers AW2, Wolf R1. Chem Commun (Camb). 2016 Apr 25. [Epub ahead of print]
A new reaction mode for bicyclo[1.1.0]tetraphosphabutanes is reported. The C[double bond, length as m-dash]S and C[double bond, length as m-dash]N bonds of phenyl isothiocyanate reversibly insert into a P-P bond of [{CpNi(IMes)}2(μ-η1:η1-P4)] (, IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazolin-2-ylidene), forming isomers and . X-ray crystallography and 31P{1H} NMR spectroscopy revealed similar bicyclo[3.1.0]heterohexane structures for these compounds.