2(1H)-Pyridinone,4-(dimethylamino)-6-methyl- - CAS 137440-96-1
Category:
Main Product
Product Name:
2(1H)-Pyridinone,4-(dimethylamino)-6-methyl-
Catalog Number:
137440-96-1
Synonyms:
137440-96-1;4-DIMETHYLAMINO-6-METHYL-1H-PYRIDIN-2-ONE;BRN5426003;2(1H)-Pyridinone,4-(dimethylamino)-6-methyl-;4-(Dimethylamino)-6-methyl-2(1H)-pyridinone;2(1H)-Pyridinone,4-(dimethylamino)-6-methyl-
CAS Number:
137440-96-1
Molecular Weight:
152.19368;g/mol
Molecular Formula:
C8H12 N2 O
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC1=CC(=CC(=O)N1)N(C)C
InChI:
InChI=1S/C8H12N2O/c1-6-4-7(10(2)3)5-8(11)9-6/h4-5H,1-3H3,(H,9,11)
InChIKey:
PPPYULUVIYHEJZ-UHFFFAOYSA-N
Chemical Structure
CAS 137440-96-1 2(1H)-Pyridinone,4-(dimethylamino)-6-methyl-

Reference Reading


1.Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type
Dollé V1, Nguyen CH, Legraverend M, Aubertin AM, Kirn A, Andreola ML, Ventura M, Tarrago-Litvak L, Bisagni E. J Med Chem. 2000 Oct 19;43(21):3949-62.
Several 4-benzyl analogues of 5-ethyl-6-methyl-4-(phenylthio)pyridin-2(1H)-ones were synthesized and evaluated for their anti-HIV-l activities. Key transformations include metalation at the 4-C-position of 5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine (5) and its coupling with benzyl bromide or benzaldehyde derivatives. Biological studies revealed that some of the new 4-benzylpyridinones show potent HIV-1 specific reverse transcriptase inhibitory properties. Compounds 14, 19, and 27, which inhibit the replication of HIV-1 in CEM-SS cells, with IC(50) values ranging from 0.2 to 6 nM are the most active compounds in this series. Biochemical studies showed that compound 27 strongly inhibited the activity of a recombinant HIV-1 RT. Moreover, the infectivity of isolated HIV-1 particles was severely decreased after exposure to compound 27. Although cross resistance is frequently observed between non-nucleoside reverse transcriptase inhibitors, compound 27 was capable of inhibiting a virus resistant to nevirapine with an IC(50) of 40 nM.