2-(1,1'-biphenyl-4-yl)-1,2,4-triazole(5,1-a)isoquinoline - CAS 75318-62-6

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Category
Main Product
Product Name
2-(1,1'-biphenyl-4-yl)-1,2,4-triazole(5,1-a)isoquinoline
Catalog Number
75318-62-6
Synonyms
2-(1,1'-biphenyl-4-yl)-1,2,4-triazole(5,1-a)isoquinoline
CAS Number
75318-62-6
Molecular Weight
0
Molecular Formula
C22H15N3
COA
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MSDS
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Structure
CAS 75318-62-6 2-(1,1'-biphenyl-4-yl)-1,2,4-triazole(5,1-a)isoquinoline
Specification
Purity
95%
Density
1.21g/cm3
Reference Reading
1.2-(1,1'-Biphenyl-4-yl)- 1,2,4-tria
Galliani G, Guzzi U, Tarzia G, Assandri A. J Vet Pharmacol Ther. 1986 Sep;9(3):246-53.
In the search for second generation post-coital pregnancy terminating agents belonging to the class of 2-phenyl-triazole[5,1-a]isoquinolines, the contragestational profile of (1,1'-biphenyl)-4-yl-1,2,4-triazole[5,1-a]isoquinoline, referred to as L 14105, was investigated in hamsters, rats, and bitches. Following subcutaneous or intramuscular administration in oily vehicles, L 14105 shows a very high anti-fertility activity in the three animal species, being from 1.8 to 2.5 times more effective than the parent drug, DL 717-IT. Unlike DL 717-IT, L 14105 possesses a high activity when administered by the oral route. The results obtained in the bitch make it confirm its potential use as a new orally active agent for the interruption of unwanted pregnancies.
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