(1R,2R)-2-amino cyclopetanecarboxylic acid hydrochloride - CAS 158414-44-9
Catalog number: 158414-44-9
Category: Main Product
Molecular Formula:
C6H11NO2?HCl
Molecular Weight:
165.62
COA:
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Purity:
95%
Synonyms:
(1R,2R)-2-AMINO-CYCLOPETANECARBOXYLIC ACID HYDROCHLORIDE SALT; (1R,2R)-2-amino cyclopetanecarboxylic acid hydrochloride; (1R,2R)-(-)-2-Amino-1-cyclopentanecarboxylic acid hydrochloride
MSDS:
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InChIKey:
LVBDVNLIEHCCTP-TYSVMGFPSA-N
InChI:
InChI=1S/C6H11NO2.ClH/c7-5-3-1-2-4(5)6(8)9;/h4-5H,1-3,7H2,(H,8,9);1H/t4-,5-;/m1./s1
Canonical SMILES:
C1CC(C(C1)N)C(=O)O.Cl
1.Synaptic strength at the temporoammonic input to the hippocampal CA1 region in vivo is regulated by NMDA receptors, metabotropic glutamate receptors and voltage-gated calcium channels.
Aksoy-Aksel A1, Manahan-Vaughan D2. Neuroscience. 2015 Nov 19;309:191-9. doi: 10.1016/j.neuroscience.2015.03.014. Epub 2015 Mar 17.
The hippocampal CA1 region receives cortical information via two main inputs: directly via the perforant (temporoammonic) path (pp-CA1 synapse) and indirectly via the tri-synaptic pathway. Although synaptic plasticity has been reported at the pp-CA1 synapse of freely behaving animals, the mechanisms underlying this phenomenon have not been investigated. Here, we explored whether long-term potentiation (LTP) at the pp-CA1 synapse in freely behaving rats requires activation of N-methyl-d-aspartate receptors (NMDAR) and L-type voltage-gated calcium channels (VGCCs). As group II metabotropic glutamate (mGlu) receptors are densely localized on presynaptic terminals of the perforant path, and are important for certain forms of hippocampal synaptic plasticity, we also explored whether group II mGlu receptors affect LTP at the pp-CA1 synapse and/or regulate basal synaptic transmission at this synapse in vivo. In adult male rats, high-frequency stimulation (200Hz) given as 3, or 10 trains, resulted in robust LTP that lasted for at least 4h in pp-CA1 or pp-dentate gyrus (DG) synapses, respectively.
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CAS 158414-44-9 (1R,2R)-2-amino cyclopetanecarboxylic acid hydrochloride

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