||Cyclopentanecarboxylic acid, 2-amino-, (1R,2R)- (9CI); (1R,2R)-2-AMINO-CYCLOPETANECARBOXYLIC ACID; (1R,2R)-(-)-2-Amino-1-cyclopentanecarboxylic acid
1.[New enzymatic strategies for enantiomers of lactams and amino acids].
Forró E1. Acta Pharm Hung. 2011;81(3):125-33.
To fulfil the requirements of modern go-ahead research, new direct and indirect enzymatic strategies and new techniques have been devised for the preparation of enantiopure beta- and gamma-lactams and beta- and gamma-amino acids, and some of them have been scaled up. For example, a formal total synthesis of enantiopure Anatoxina, a neurotoxic alkaloid, but a potent and stereospecific agonist at nicotinic acetylcholine receptors has been introduced. An efficient and very simple method has been developed for the synthesis of the antibacterial cispentacin [(1R,2S)-2-amino-1-cyclopentanecarboxylic acid] and 8 new derivatives. A highly efficient enzymatic procedure has been elaborated for the synthesis of the blockbuster drug Abacavir and Carbovir intermediate (1S,4R)-4-aminocyclopent-2-ene-1-carboxylic acid. The first enzymatic method has been devised for the synthesis of (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid, the intermediate for the new antidiabetic drug Sitagliptine.