17α-Hydroxyprogesterone Caproate - CAS 630-56-8
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
17α-Hydroxyprogesterone Caproate
Catalog Number:
630-56-8
Synonyms:
Primolut Depot; HYDROXYPROGESTERONE CAPROATE; [(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] hexanoate;
CAS Number:
630-56-8
Description:
17α-Hydroxyprogesterone Caproate , a synthetic steroidal progestin, is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid used in the treatment of threatened miscarriage, gynecological disorders such as dysmenorrhea, premenstrual synd
Molecular Weight:
428.6
Molecular Formula:
C27H40O4
Quantity:
Grams-Kilos
Quality Standard:
Enterprise Standard/USP
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CCCCCC(=O)OC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)C(=O)C
InChI:
1S/C27H40O4/c1-5-6-7-8-24(30)31-27(18(2)28)16-13-23-21-10-9-19-17-20(29)11-14-25(19,3)22(21)12-15-26(23,27)4/h17,21-23H,5-16H2,1-4H3/t21-,22+,23+,25+,26+,27+/m1/s1
InChIKey:
DOMWKUIIPQCAJU-LJHIYBGHSA-N
Targets:
Others
Current Developer:
Squibb
Chemical Structure
CAS 630-56-8 17α-Hydroxyprogesterone Caproate

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Reference Reading


1.Prevention of preterm delivery with compounded 17a-hydroxyprogesterone caproate.
Reed-Kane D Pharmd Fiacp Faca Fc1, Kirschbaum K Phd. Int J Pharm Compd. 2006 May-Jun;10(3):165-71.
17a-hydroxyprogesterone caproate is a naturally occurring metabolite of progesterone that is produced in significant quantities during pregnancy. The demand for 17a-hydroxyprogesterone caproate, the lack of a commercially available manufactured form approved by the US Food And Drug Administration, and publication of the results of a large trial to determine the effectivenss of the drug in the prevention of preterm delivery have spawned an increased interest in compounded formulations of the drug. The demand also has necessitated a review of the available literature and of past clinical studies, and a look at present and planned studies. Owing to the importance of this drug in pregnancy and the need for safety, accuracy in potency, and sterility in an intramuscular injection (the most common route of administration), compounding pharmacies must be in compliance with the United States Pharmacopeia Chapter 797 standards should they wish to compound this formulation.