10H-Phenothiazine-10-ethanamine,N,N,b-trimethyl- - CAS 303-14-0
Catalog number: 303-14-0
Category: Main Product
Molecular Formula:
C17H20N2S
Molecular Weight:
284.4191;g/mol
COA:
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Purity:
95%
Synonyms:
Fen-Bridal; 303-14-0; N,N-dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine; dimethyl[2-(10H-phenothiazin-10-yl)propyl]amine; Isomethazine; Prothiazin
MSDS:
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Quantity:
Data not available, please inquire.
Boiling Point:
403.4ºC at 760mmHg
Density:
1.142g/cm3
InChIKey:
CGNHCKZJGQDWBG-UHFFFAOYSA-N
InChI:
InChI=1S/C17H20N2S/c1-13(12-18(2)3)19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
Canonical SMILES:
CC(CN(C)C)N1C2=CC=CC=C2SC3=CC=CC=C31
1.NTP Toxicology and Carcinogenesis Studies of Promethazine Hydrochloride (CAS No. 58-33-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
National Toxicology Program. Natl Toxicol Program Tech Rep Ser. 1993 Dec;425:1-272.
Promethazine hydrochloride is a drug used for the management of allergic conditions, motion sickness and nausea, and as a sedative to (treat psychiatric disorders. This drug was nominated for testing by the Food and Drug Administration because of its widespread use in human medicine and because of lack of data on its potential carcinogenicity. Oral administration is the most common route of human exposure. Toxicology and carcinogenicity studies were conducted by administering promethazine hydrochloride (>99% pure) in distilled water by gavage to groups of male and female F344/N rats and B6C3F1 mice for 16 days, 13 weeks, or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium, in cultured Chinese hamster ovary cells, and in Drosophila melanogaster. 16-DAY STUDY IN RATS: Groups of five male and five female rats received 0, 18.5, 55.5, 166.5, 500, or 1,500 mg promethazine hydrochloride/kg body weight once daily, 5 days per week for a total of 12 doses in a 16-day period.
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CAS 303-14-0 10H-Phenothiazine-10-ethanamine,N,N,b-trimethyl-

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