10-Oxo Docetaxel - CAS 167074-97-7
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
10-Oxo Docetaxel
Catalog Number:
167074-97-7
Synonyms:
Docetaxel Impurity
CAS Number:
167074-97-7
Description:
A novel taxoid having remarkable anti-tumor properties. Docetaxel intermediate. This product is unstable in solution, epimerize.
Molecular Weight:
805.86
Molecular Formula:
C43H51NO14
COA:
Inquire
MSDS:
Inquire
Targets:
Others
Chemical Structure
CAS 167074-97-7 10-Oxo Docetaxel

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Reference Reading


1.Isolation and characterization of degradation impurities in docetaxel drug substance and its formulation.
Kumar D1, Tomar RS, Deolia SK, Mitra M, Mukherjee R, Burman AC. J Pharm Biomed Anal. 2007 Mar 12;43(4):1228-35. Epub 2006 Nov 28.
The degradation of docetaxel drug substance and its injection formulation has been investigated. The majority of impurities were observed in a base degradation study and all five degradation products were characterized. These impurities were isolated, enriched and were subjected to mass and NMR spectral studies. Based on the spectral data, these were characterized as 10-deacetyl baccatin III, 7-epi-10-deacetyl baccatin III, 7-epi-10-oxo-10-deacetyl baccatin III, 7-epi docetaxel and 7-epi-10-oxo-docetaxel, respectively. The last two impurities were also detected in the stability study of docetaxel formulation. Out of these degradation impurities two substances have been previously identified while the other three previously unreported.