1.[The blood coagulation system under overdoses of the copolymer of 1-vinyl-3-methylimidazole iodide with the diethyl ether of maleic acid demonstrating antiheparin activity].
Afanas'eva GV, Smirnov AI, Efimov VS. Eksp Klin Farmakol. 1993 Nov-Dec;56(6):32-4.
The effects of the active heparin antagonist--1-vinyl-3-methylimidazolium iodide-maleic acid diethyl ether copolymer--on the blood coagulative system were investigated. The effect of polycation was shown to appear only when the therapeutical dose was significantly increased and to manifest itself in the development of hypocoagulation. Hypocoagulative changes occurred only by inhibiting the activity of clotting factors V and VIII. Also, there was a moderate reduction in platelet counts.