1-Pyrenyl b-D-glucuronide - CAS 154717-05-2
Category:
Carbohydrates
Product Name:
1-Pyrenyl b-D-glucuronide
Synonyms:
1-Hydroxypyrene-b-D-glucuronide
CAS Number:
154717-05-2
Molecular Weight:
394.37
Molecular Formula:
C22H18O7
COA:
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MSDS:
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Structure:
Monosaccharides
Chemical Structure
CAS 154717-05-2 1-Pyrenyl b-D-glucuronide

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Reference Reading


1.Simultaneous analysis of naphthols, phenanthrols, and 1-hydroxypyrene in urine as biomarkers of polycyclic aromatic hydrocarbon exposure: intraindividual variance in the urinary metabolite excretion profiles caused by intervention with beta-naphthoflavone
Elovaara E1, Väänänen V, Mikkola J. Arch Toxicol. 2003 Apr;77(4):183-93. Epub 2003 Feb 12.
Two fluorimetric HPLC methods are described for the quantification of naphthols, phenanthrols and 1-hydroxypyrene (1-OHP) in urine specimens obtained from male Wistar rats exposed to naphthalene, phenanthrene and pyrene. The polycyclic aromatic hydrocarbons (PAHs) were given intraperitoneally, either alone (1.0 mmol/kg body weight) or as an equimolar mixture (0.33 mmol/kg), using the same dosages for repeated treatments on week 1 and week 2. Between these treatments, PAH-metabolizing activities encoded by aryl hydrocarbon (Ah) receptor-controlled genes were induced in the rats with beta-naphthoflavone (betaNF). Chromatographic separation of five phenanthrols (1-, 2-, 3-, 4-, and 9-isomers) was accomplished using two different RP C-18 columns. Despite selective detection (programmable wavelengths), the quantification limits in the urine ranged widely: 1-OHP (0.18 microg/l) <phenanthrols (0.34-0.45 microg/l) <2-naphthol (1.5 microg/l) <1-naphthol (4 micro g/l).