|Description||1-O-Acetylbritannilactone significantly reduced melanin production in a dose-dependent manner with IC50 value of 13.3 uM. inhibited melanogenesis by activating extracellular signal-regulated kinase (ERK) and Akt signaling and also inhibiting cAMP related binding protein, which regulates its downstream pathway, including tyrosinase, tyrosinase related protein-1 and TRP-2. ABL (5, 10, 20 micrommol/l) had several concentration-dependent effects, including inhibition of lipopolysaccharide (LPS)-induced PGE(2) production and COX-2 expression, and blockade of NF-kappaB activation and translocation. 1-O-Acetylbritannilactone is a potent inhibitor of LPS-stimulated VSMC inflammatory responses through blockade of NF-kappaB activity and inhibition of inflammatory gene COX-2 expression.|
Notoginsenoside Ft1, a new saponin solated from the leaves of P. notoginseng, as a stimulator of angiogenesis it is more potent compared with other bioactive sa...
Ginsenoside Ro, the predominant ginsenoside in the rhizome, shows no hemolytic nor cytotoxic activities.
Urethane is an ester of carbamic acid used as an antineoplastic agent and for other medicinal purposes.
Ascorbic acid is a naturally occurring organic compound with antioxidant properties.
Brotianide, with anti-fasciolidal activity, is an anthelminthic drug for the treatment of severe infections on animals to remove larvae.
2(acute)-Deoxyguanosine is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. It is a purine nucleoside that u...
Mycophenolic acid is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.It inhi...
Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms used in sunscreens and other cosmetics
Liothyronine Sodium is the most potent form of thyroid hormone acting on the body to increase the basal metabolic rate, affect protein synthesis.
2-Aminoheptane, a fatty Amine compound, is commonly used in proteomics research and could also be used to product some A3 adenosine receptor antagonists.
NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility.
Idramantone, an immune agonist, can be used to prepare adamantane substituted guanylhydrazones.
Icariin is a flavonol glycoside, a type of flavonoid. Icariin is a PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.
L-p-Hydroxyphenyglycines a carnitine is a palmitoyltransferase-1 inhibitor, improves whole-body glucose tolerance and insulin sensitivity in high-fat diet-induc...
SP-420 is a desferrithiocin analogue with iron-clearing efficiency. Its ICE value is 26.7. It is more potent than desferrithiocin.
Adozelesin is an experimental antitumor drug of the duocarmycin class. It is the first of a class of DNA-sequence-selective alkylating agents. It binds to and a...
ABT116 is an antagonist of transient receptor potential vanilloid type 1.
CVT10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) with IC50 value of 29nM, thereby inhibiting dopamine synthesis. It ...
Cloquintocet-mexyl is a herbicide. It is used to control coarse annual grass of the family poaceae (gramineae). lt was developed by the swiss ciba geigy in the ...
PD 138142 is a water soluble Sterol O-acyltransferase inhibitor. Triacylglycerol secretion is decreased in the presence of PD-138142-15. Preclinical development...