1-O-Acetylbritannilactone - CAS 33627-41-7
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
1-O-Acetylbritannilactone
Catalog Number:
33627-41-7
Synonyms:
Inulicin
CAS Number:
33627-41-7
Description:
1-O-Acetylbritannilactone significantly reduced melanin production in a dose-dependent manner with IC50 value of 13.3 uM. inhibited melanogenesis by activating extracellular signal-regulated kinase (ERK) and Akt signaling and also inhibiting cAMP related binding protein, which regulates its downstream pathway, including tyrosinase, tyrosinase related protein-1 and TRP-2. ABL (5, 10, 20 micrommol/l) had several concentration-dependent effects, including inhibition of lipopolysaccharide (LPS)-induced PGE(2) production and COX-2 expression, and blockade of NF-kappaB activation and translocation. 1-O-Acetylbritannilactone is a potent inhibitor of LPS-stimulated VSMC inflammatory responses through blockade of NF-kappaB activity and inhibition of inflammatory gene COX-2 expression.
Molecular Weight:
308.37
Molecular Formula:
C17H24O5
COA:
Inquire
MSDS:
Inquire
Targets:
Others
Chemical Structure
CAS 33627-41-7 1-O-Acetylbritannilactone

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