|Description||1-O-Acetylbritannilactone significantly reduced melanin production in a dose-dependent manner with IC50 value of 13.3 uM. inhibited melanogenesis by activating extracellular signal-regulated kinase (ERK) and Akt signaling and also inhibiting cAMP related binding protein, which regulates its downstream pathway, including tyrosinase, tyrosinase related protein-1 and TRP-2. ABL (5, 10, 20 micrommol/l) had several concentration-dependent effects, including inhibition of lipopolysaccharide (LPS)-induced PGE(2) production and COX-2 expression, and blockade of NF-kappaB activation and translocation. 1-O-Acetylbritannilactone is a potent inhibitor of LPS-stimulated VSMC inflammatory responses through blockade of NF-kappaB activity and inhibition of inflammatory gene COX-2 expression.|
Terbutryn is a chemical compound with a triazine ring as a basic structure. It is used as a herbicide. It also acts as an inhibitor of photosynthesis. It is abs...
Adrenal medullary stress hormone, mediator of the fight-or-flight response; and the primary neurotransmitter in the post-ganglionic sympathetic (adrenergic) ner...
NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
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CS-M1996 is a 4′-Azidocytidine analogue. It can inhibit Hepatitis C virus replication.
Isopropamide is a long-acting anticholinergic drug. It can be used for the treatment of peptic ulcers and other gastrointestinal disorders including hyperacidit...
Deferoxamine mesylate, an iron chelator, could be used in the treatment of acute iron poisoning, sickle cell diseases and it is also found to have some extent o...
Collagen proline hydroxylase inhibitor-1
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The hydrochloride salt form of isotope labelled Ivabradine which is an inhibitor of If current of the sinoatrial node and could used in the treatment of Chronic...
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Oxytocin acetate is a mammalian neurohypophysial hormone. Its actions are mediated by specific, high-affinity oxytocin receptors. Oxytocin is normally produced ...