Lck Inhibitor is a small-molecule inhibitor. It takes participate in the T-cell receptor (TCR) signal transduction and affects the expression of genes associate...
CHMFL-ABL-053 is an orally available, small molecule multi-kinase inhibitor for BCR-ABL (IC50= 70 nM),SRC (IC50 = 90 nM) and p38 kinases (IC50 = 62 nM). CHMFL-A...
Scutellarein is a flavonoid isolated from Scutellaria lateriflora could improve neuronal injury.
HG-9-91-01，a small molecule inhibitor that targets specificly salt-inducible kinase (SIKs) IC50: SIK1=0.92 nM; SIK2=6.6 nM; SIK3=9.6 nM
A-419259 is a potent inhibitor of Src family kinases. IC50 values for src, lck, blk, csk, fyn and lyn range between 15 and 50 nM.
KX2-391 is an orally bioavailable small molecule Src kinase inhibitor with potential antineoplastic activity. Unlike other Src kinase inhibitors which bind to t...
Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively.
KX1-004 is an Src-protein tyrosine kinase inhibitor to reduce cisplatin ototoxicity while preserving its antitumor effect. KX1-004 has been used to protect the...
TG 100572 is a multi-targeted kinase inhibitor that inhibits select growth factor receptor tyrosine kinases and Src familt kinases.
AP-2216, designed to bind selectively to the Src SH2 domain by targeting a cysteine residue, has the potential to be further developed for treating osteoporosis...
T338C Src-IN-1, a pyrazolopyrimidine detivative, has been found effective T338C inhibition and could be significant for determing the effect of kinases by Chemi...
AP-22408, a Src tyrosine kinase inhibitor, is an orally bioavailable phosphotyrosine mimic resulting from a structurebased design.
eCF506 is a potent and highl selective inhibitor towards Src tyrosine kinase with a 1000-fold selectivity over ABL. eCF506 inhibits SRC at subnanomolar concentr...
AMG-47a is a potent inhibitor of Lck and T cell proliferation. It has anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in...
An analogue of WEHI-345, a pyrazolo-pyridine derivative, is a protein kinase inhibitor and could be significant for studying the mechanism of cancer.
CGP 77675 selectively inhibited phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50: 5-20 and 40 nM, respectively).
A 419259 trihydrochloride
Potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including...