1-Naphthyl PP1 hydrochloride - CAS 956025-47-1
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
1-Naphthyl PP1 hydrochloride
Catalog Number:
956025-47-1
Synonyms:
1-Tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine hydrochloride;1-NA-PP 1 hydrochloride
CAS Number:
956025-47-1
Description:
1-Naphthyl PP1 hydrochloride is a selective inhibitor of src family kinases, including v-Src and c-Fyn, tyrosine kinase c-Abl and CAMK II with IC50 values of 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively. It was considerably more potent and showed distinct substituent effects at the pyrazolopyrimidine core. It was cell-active, and potently blocked prostate cancer cell proliferation by inducing G2/M arrest.
Molecular Weight:
353.85
Molecular Formula:
C19H20ClN5
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC(C)(C)N1C2=C(C(=N1)C3=CC=CC4=CC=CC=C43)C(=NC=N2)N.Cl
InChI:
InChI=1S/C19H19N5.ClH/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14;/h4-11H,1-3H3,(H2,20,21,22);1H
InChIKey:
UKLRSYUALPIALU-UHFFFAOYSA-N
Targets:
Src

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