(1-Methylethyl)carbamic Acid Phenyl Ester - CAS 17614-10-7
Category:
Main Product
Product Name:
(1-Methylethyl)carbamic Acid Phenyl Ester
Catalog Number:
17614-10-7
Synonyms:
N-(1-Methylethyl)carbamic Acid Phenyl Ester; Phenyl Isopropylcarbamate; NSC 190576;
CAS Number:
17614-10-7
Molecular Weight:
179.22
Molecular Formula:
C10H13NO2
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC(C)NC(=O)OC1=CC=CC=C1
InChI:
InChI=1S/C10H13NO2/c1-8(2)11-10(12)13-9-6-4-3-5-7-9/h3-8H,1-2H3,(H,11,12)
InChIKey:
RJUVFGTVVVYSFK-UHFFFAOYSA-N
Chemical Structure
CAS 17614-10-7 (1-Methylethyl)carbamic Acid Phenyl Ester

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Reference Reading


1.Hepatic microsomal induction profile of carbamic acid [[2,6-bis(1- methylethyl)phenoxy] sulfonyl]-2,6-bis(1-methylethyl) phenyl ester, monosodium salt (PD138142-15), a novel lipid regulating agent.
Robertson DG1, Krause BR, Welty DF, Wolfgang GH, Graziano MJ, Pilcher GD, Urda E. Biochem Pharmacol. 1995 Mar 15;49(6):799-808.
Induction of hepatic microsomal cytochrome P450 produced by carbamic acid [2,6-bis(1-methylethyl)phenoxy]sulfonyl]-2,6-bis(1-methylethyl) phenyl ester, monosodium salt (PD138142-15), a novel water-soluble inhibitor of acyl-CoA: cholesterol acyltransferase, was examined in male and female rats, dogs, and monkeys, and in male guinea pigs. Relative to control, PD138142-15 increased hepatic microsomal total spectral P450 in all species examined. Hepatic microsomal ethoxyresorufin-O-deethylase, pentoxyresorufin-O-dealkylase, and peroxisomal carnitine acetyltransferase activities and cyanide-insensitive Beta-oxidation were affected only marginally. Erythromycin-N-demethylase activity was increased (2- to 6-fold) in all three species in which it was examined (rat, dog and pig). Marked increases in immunoreactive P450 3A were noted in the rats and dogs, while slight increases were seen in monkeys. Pharmacokinetic studies of PD138142-15 in rats and dogs revealed pronounced decreases (80-90%) in plasma Cmax and AUC within 2 weeks of initiation of daily dosing.