1,7-Heptanedicarboxylic Acid - CAS 123-99-9
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
1,7-Heptanedicarboxylic Acid
Catalog Number:
123-99-9
Synonyms:
Azelaic acid; NONANEDIOIC ACID; 123-99-9; Finacea; Azelex; Anchoic acid
CAS Number:
123-99-9
Description:
Azelaic acid, produced by ozone cracking of unsaturated fatty acid, could be commonly used in grease, cosmetics and pharmaceuticals.
Molecular Weight:
188.22
Molecular Formula:
C9H16O4
Quantity:
Grams-Kilos
Quality Standard:
Cosetic Grade
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
C(CCCC(=O)O)CCCC(=O)O
InChI:
InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChIKey:
BDJRBEYXGGNYIS-UHFFFAOYSA-N
Targets:
Others
Chemical Structure
CAS 123-99-9 1,7-Heptanedicarboxylic Acid

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Reference Reading


1.Medium and Long Chain Fatty Acids Differentially Modulate Apoptosis and Release of Inflammatory Cytokines in Human Liver Cells.
Li L1, Wang B1, Yu P2, Wen X1, Gong D3, Zeng Z2,4. J Food Sci. 2016 May 3. doi: 10.1111/1750-3841.13321. [Epub ahead of print]
Medium chain fatty acids (MCFA) can be more easily absorbed and supply energy more rapidly than long chain fatty acids (LCFA). However, little is known about the inflammatory response by the treatment of MCFA in human liver cells. Thus this study used human liver cells (LO2) to evaluate the effects of MCFA on apoptosis and inflammatory response. Tetrazolim-based colorimetric assay and lactate dehydrogenase assay were used to measure the viability of LO2 cells, isolated spleens and liver cells from BALB/C mice. Inverted fluorescence microscopy and flow cytometry were used to assess the cell apoptosis. Activity of superoxide dismutase and malondialdehyde level were measured to determine the oxidative damage. mRNA or protein levels of classical pro-inflammatory cytokines were analyzed by quantitative real-time polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay and western blotting. The results showed that the liver cells treated with the fatty acids at 200 μM for 24 h exhibited good viability.
2.Portal-drained viscera heat production in Iberian pigs fed betaine and conjugated linoleic acid supplemented diets.
Rojas-Cano ML1, Lachica M1, Lara L1, Haro A1, Fernández-Fígares I1. J Sci Food Agric. 2016 May 4. doi: 10.1002/jsfa.7788. [Epub ahead of print]
BACKGROUND: Betaine and conjugated linoleic acid (CLA) may alter growth and body composition in pigs although their mode of action is not well understood. Portal-drained viscera (PDV) have a disproportionate influence with respect to their masses and this fact may affect the productivity of more profitable tissues. The objective of this study was to determine if the use of betaine and/or CLA in the diet affects PDV heat production.