1-(4-Fluorophenyl)cyclohexanecarboxylic acid - CAS 214263-00-0
Catalog number:
214263-00-0
Category:
Main Product
Molecular Formula:
C13H15FO2
Molecular Weight:
222.26
COA:
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Purity:
95%
Synonyms:
1-(4-FLUOROPHENYL)CYCLOHEXANECARBOXYLIC ACID, 98; 1-(4-FLUOROPHENYL)CYCLOHEXANECARBOXYLIC ACID 98%
MSDS:
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Boiling Point:
349.7ºC at 760 mmHg
Melting Point:
136ºC
InChIKey:
XQKPSVJXJIFYAU-UHFFFAOYSA-N
InChI:
InChI=1S/C13H15FO2/c14-11-6-4-10(5-7-11)13(12(15)16)8-2-1-3-9-13/h4-7H,1-3,8-9H2,(H,15,16)
Canonical SMILES:
C1CCC(CC1)(C2=CC=C(C=C2)F)C(=O)O
Physical Description:
1-(4-Fluorophenyl)cyclohexanecarboxylic acid 98% (1g)
1.Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.
Thomas JB1, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP. J Med Chem. 2014 Jun 26;57(12):5318-32. doi: 10.1021/jm5003843. Epub 2014 Jun 5.
Compounds active at neurotensin receptors (NTS1 and NTS2) exert analgesic effects on different types of nociceptive modalities, including thermal, mechanical, and chemical stimuli. The NTS2 preferring peptide JMV-431 (2) and the NTS2 selective nonpeptide compound levocabastine (6) have been shown to be effective in relieving the pain associated with peripheral neuropathies. With the aim of identifying novel nonpeptide compounds selective for NTS2, we examined analogues of SR48692 (5a) using a FLIPR calcium assay in CHO cells stably expressing rat NTS2. This led to the discovery of the NTS2 selective nonpeptide compound 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid (NTRC-739, 7b) starting from the nonselective compound 5a.
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CAS 214263-00-0 1-(4-Fluorophenyl)cyclohexanecarboxylic acid

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