(1,2,3,4-Tetrahydroquinolin-2-yl)methanol - CAS 40971-36-6
Main Product
Product Name:
Catalog Number:
1,2,3,4-tetrahydroquinolin-2-ylmethanol; (1,2,3,4-Tetrahydroquinolin-2-yl)methanol; 40971-36-6; 1,2,3,4-Tetrahydro-2-quinolinemethanol; 2-hydroxymethyl-1,2,3,4-tetrahydroquinoline; SCHEMBL700861
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Chemical Structure
CAS 40971-36-6 (1,2,3,4-Tetrahydroquinolin-2-yl)methanol

Reference Reading

1.Metal- and Protection-Free [4 + 2] Cycloadditions of Alkynes with Azadienes: Assembly of Functionalized Quinolines.
Saunthwal RK1, Patel M1, Verma AK1. Org Lett. 2016 Apr 27. [Epub ahead of print]
A base promoted, protection-free, and regioselective synthesis of highly functionalized quinolines via [4 + 2] cycloaddition of azadienes (generated in situ from o-aminobenzyl alcohol) with internal alkynes has been discovered. The reaction tolerates a wide variety of functional groups which has been successfully extended with diynes, (2-aminopyridin-3-yl)methanol, and 1,4-bis(phenylethynyl)benzene to afford (Z)-phenyl-2-styrylquinolines, phenylnaphthyridine, and alkyne-substituted quinolines, respectively. The proposed mechanism and significant role of the solvent were well supported by isolating the azadiene intermediate and deuterium-labeling studies.
2.Optimization of chemometric approaches for the extraction of isorhamnetin-3-O-rutinoside from Calendula officinalis L.
Moraes ML1, da Silva HD2, Blanes L3, Dobb P3, Tavares MF4. J Pharm Biomed Anal. 2016 Apr 20;125:408-414. doi: 10.1016/j.jpba.2016.04.017. [Epub ahead of print]
The application of Design of Experiments (DoE) to the determination of optimum conditions for an extraction process relies on the correct selection of mathematical models. The linear model is the one typically used; however, in some cases it does not always have superior performance, ignoring the real nature of the data and its appropriate descriptive model. In order to evaluate the extraction efficiency of isorhamnetin-3-O-rutinoside from flowers of Calendula officinalis L. a multivariate factorial analysis was used. Simulations were conducted using linear, quadratic, full cubic and special cubic models. A Simplex-Centroid design was chosen as it delivered greater precision with only minor errors versus other models tested. Analyses were performed by capillary zone electrophoresis using sodium tetraborate buffer (40mmolL-1, pH 9.4) containing 10% methanol. The detection was linear over a range of 8.0-50.0mgL-1 (r2=0.996), and the limits of detection (LOD) and quantification (LOQ) for isorhamnetin-3-O-rutinoside were 3.